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亓立峰

亓立峰.jpg

亓立峰 博士

副研究员,博士生导师
同济大学生物医学工程与纳米科学研究院
联系地址:上海市赤峰路67号 200092
联系电话:021-65983706(815) 
Email:qi@focusgen.com

学术经历简介:
亓立峰,博士,华盛顿大学博士后。现任同济大学医学院副研究员,博士生导师。已在国际权威期刊JACS、ACS nano、Biomacromolecules、Journal Material Chemistry、European Journal of Cancer.等杂志发表SCI科研论文20余篇。论文被他引超过1500次,单篇论文他引超过200余次。其中在JACS, ACS nano,European Journal of Cancer发表的论文被美国癌症研究所重点报道,在ACS nano发表论文被列为当期重点推荐文章,并在该杂志年度总结中作为亮点论文介绍。申请及获授权发明专利6项。作为项目负责人已结题及在研国家自然科学基金、教育部博士点基金、教育部留学回国人员基金、上海市自然科学基金等课题6项。

部分代表论文:

Chen Y., Wang J., Wang J., Wang L., Tan X., Tu K., Tong X.*, and Qi L.* Aptamer Functionalized Cisplatin-Albumin Nanoparticles for Targeted Delivery to Epidermal Growth Factor Receptor Positive Cervical Cancer. J. Biomed. Nanotechnol. 2016, 12: 1–11. (IF:5.9)

Wang L., Wu W., Wang J., Wang* J., Tong X., Hu Q., Qi L*. Highly Efficient Gab2 siRNA Delivery to Ovarian Cancer Cells mediated by Chitosan-polyethyleneimine Nanoparticles. Journal of Material Chemistry B. 2016, in press. (IF:4.7)

Qi L.*, Liu J., Zhu H., Li Z., Lu K., Li T., Shi D*. Inhibition of glioma proliferation and migration by magnetic nanoparticle mediated JAM-2 silencing. J. Mater. Chem. B, 2014, DOI:10.1039/c4tb00954a.

Qi L*, Shao W, Shi D. JAM-2 siRNA intracellular delivery and real-time imaging by proton-sponge coated quantum dots. J. Mater. Chem. B, 2013, 1, 654-660. (IF:6.1). 

Qi L*, Wu S, Zheng S, Fu H, Cui D. Cell permeable magnetic nanoparticles for siRNA delivery.Biomolecules, 2012, 13(9), 2723-2730. (IF:5.47).

Shao W, Zheng S, Qi L*. Recent patents on nanosensor for tumor biomarker detection. Nano Biomed. Eng. 2011, 3(1):66-72. 

Qi L, Zheng S, Lin B. Recent patents on imaging nanoprobes for brain tumor diagnosis and therapy.Recent Pat Biotechnol. 2010 Jun 1;4(2):130-5. (IF:5.2)

Lin, B, Jin, S, Wang, J, Qi L,et.al Meeting report: the 2009 Westlake International Conference on Personalized Medicine,《OMICS》, V0l.13(4), 2009. 

Qi L, Gao X. Quantum Dot-Amphipol Nanocomplex for Intracellular Delivery and Real-Time Imaging of siRNA. ACS nano, 2008, 2(7), 1403–1410 (IF: 12.06). 

Yezhelyev M.V., Qi L, O’Regan R.M., Nie S., Gao X. Proton-sponge-coated quantum dots for siRNA delivery and intracellular imaging. J. Am. Chem. Soc. 2008, 130, 9006-9012 (IF:10.7)

Qi L, Gao X. Emerging application of quantum dots for drug delivery and therapy. Expert Opin. Drug Deliv. 2008; 5:263-267 (,IF:4.8). 

Qi L, Pal S, Dutta P, Seehra M, Pei M. Morphology controllable nanostructured chitosan matrix and its cytocompatibility. J. Biomed. Mater. Res. A. 2007 Dec. 18 online (IF:2.8). 

Qi L*, Xu Z, Chen M. In vitro and in vivo suppression of growth of human hepatoma BEL7402 cells by chitosan nanoparticles. Eur. J. Cancer 2007; 43:184-93 (IF:5.06). 

11.Qi L, Xu Z. In vivo antitumor activity of chitosan nanoparticles. Bioorg. Med. Chem. Lett. 2006, 16, 4243-5 (IF2.6). 

Qi L, Xu Z, Li Y, Jiang X, Han X. In vitro effects of chitosan nanoparticles on proliferation of human gastric carcinoma cell line MGC803. World J Gastroenterol. 2005; 11(33): 5136-5141 (IF:3.3).

Qi L, Xu Z, Jiang X, Li Y, Wang M. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg. Med. Chem. Lett. 2005; 15: 1357-1399. 

Qi L, Xu Z, Jiang X, Hu C, Zou X. Preparation and antibacterial activity of chitosan nanoparticles,Carbohydr. Res. 2004; 339 (16): 2693-2700.

Qi L, Xu Z. Lead sorption from aqueous solutions on chitosan nanoparticles, Colloids Surfaces A: Physicochem Eng Aspects 2004; 251: 183-190.

 


大会报告:

[1] Qi L, Dutta P, Pas S, Seehra M, Pei M. Preparation and characterization of chitosan nanocrystal. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 755. 
[2] Qi L, Dutta P, Pas S, Seehra M, Pei M. Chitosan nanaocrystals: A potential Biomaterial for tissue engineering application. NSTI Nanotech 2007, Bio Nano Material & Tissues Syposium, Santa Clara, California, May 20-24, 2007, abstract number 770.
[3] Gao X. Qi L. Quantum dot for efficient delivery and real-time imaging of siRNA. ACS 236th National meeting, Aug. 17-21, 2008.

目前在研课题:

[1] 国家自然科学基金,批准号:81371682,多模态层级靶向脑胶质瘤siRNA纳米影像载体系统可控制备与抑瘤活性研究。2014.1.1~2017.12.30。 
[2] 上海市自然科学基金,批准号:13ZR1443900,新型抗胶质瘤多模态纳米影像siRNA载体系统构建及作用机制研究。2013.7.1-2016.6.30。 
主要已结题项目: 
[1] 国家自然科学基金,批准号:30900345,新型分子影像siRNA纳米载体系统的构建及其在乳腺癌应用基础研究。项目起止日期:2010.1.1~2012.12.30。 
[2] 国家教育部博士点基金-新教师类,批准号:J20101127,(MiR-127 和MiR-433在神经胶质瘤发生发展中的功能性研究,2010-01-01~2011-12-31)。 
[3] 教育部留学人员回国启动资金,新型分子影像siRNA纳米载体系统靶向转染脑胶质瘤细胞分子机理研究,2010.12-2012.12.



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