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董海青

董海青.jpg

董海青 博士

副研究员

同济大学生物医学工程与纳米科学研究院

地址:上海杨浦区赤峰路67号

邮编:200092

电话:+086-021-65983706-805

Email: inano_donghq@tongji.edu.cn

 

教育背景:

2004~2009年: 硕、博连读(公费生)武汉大学化学与分子科学学院

2000~2004年: 本科 黄冈师范学院化学系

 

工作经历:

2013~至今:副研究员 同济大学医学院 生物医学工程与纳米科学研究院

2011~2013:副研究员 同济大学转化医学高等研究院 时东陆课题组

2009~2011年:博士后 同济大学材料科学与工程博士后流动站

 

研究领域与兴趣:

1. 生物医用高分子及超分子自组装在生物医学及生物技术领域的应用

2. 多功能纳米药物载体在肿瘤治疗方面的应用研究

 

主持项目:

2013~2015年:上海市“晨光计划”:基于主客化学构建刺激响应纳米药物载体

2012~2014年:国家自然科学基金青年基金(21104059):超分子纳米胶束构建新策略及其药物控释应用研究

2010~2012年:中国博士后特别资助(201104268):药物分子调控的环糊精基超分子胶束的构建及其生物医用初探

2010~2011年:中国博士后基金(20100470111): 新型超分子聚合物胶束的设计与构建及其光动力治疗体外评价

2009~2011年:上海博士后基金(10R21415700):生物可降解超分子聚合物胶束的制备及其生物医学研究

 

代表性论文及专利:

    Liu QM,  Zhu HS, Qin JY,  Dong HQ*,  Du JZ*, Theranostic Vesicles Based on Bovine Serum Albumin and Poly(ethylene glycol)-block-poly(L‑lactic-co-glycolic acid) for Magnetic Resonance Imaging and Anticancer Drug Delivery, Biomacromolecules, 2014, 15, 1586-1592 (IF 5.783)

     Dong HQ,  Dong CY,  Li YY*,  Ren TB,  Shi DL*, Surface-Engineered Graphene-Based Nanomaterials for Drug Delivery,J Biomed Nanotech, 2014, 10, 2086-2106. (IF 7.578)

    Dong HQ, Dong CY, Xia WJ, Li YY, Ren TB, Self-assembled, Redox-sensitive, H-shaped Pegylated Methotrexate Conjugates with High Drug-carrying Capability for Intracellular Drug Delivery, MedChem Comm, 2014, 5, 147-152.

    Dong HQ, Li YY*, Yu JH, Song YY, Cai XJ, Liu JQ, Zhang JM, Ewing RC, Shi DL*, A Versatile Multi-Component Assembly via β-cyclodextrin Host-Guest Chemistry on Graphene for Biomedical Applications, Small 2013, 9(3), 446-456. (影响因子:8.349)

    Cai XJ, Dong HQ, Ma JP, Zhu HY, Wu W, Chu M, Li YY*, Shi DL*, Effects of spatial distribution of the nuclear localization sequence on gene transfection in catiomer–gene polyplexes, J Mater Chem B 2013,1, 1712-1721

    Dong HQ, Dong CY, Feng Y, Ren TB*, Zhang ZH, Li L, Li YY, Engineering of Peglayted Camptothecin into Core-shell Nanomicelles for Improving Solubility, Stability and Combination Delivery, MedChem Comm 2012, 3 (12), 1555-1561.

    Hu HQ, Yu JH, Li YY*, Zhao J, Dong HQ*, Engineering of a Novel Pluronic F127/Graphene Nanohybrid for pH Responsive Drug Delivery, J Biomed Mater Res A 2012, 100A, 141-148.

    Dong HQ, Li YY, Wen HY, Xu M, Liu LJ, Li ZQ, Guo FF, Shi DL, Highly Efficient Drug Delivery Nanosystem by L-Phenylalanine Triggering Based on Supramolecular Polymer Micelles, Macromol Rapid Comm 2011, 32(6), 540-545. (影响因子:4.9)

    Dong HQ, Li YY, Shi DL, Cyclodextrins/Polymer Based (Pseudo)Polyrotaxanes for Biomedical Application, Prog Chem 2011,23 (5): 914-922.

    Dong HQ, Liu LJ, Li YY, Shape Memory Behavior of Poly(L-lactide)/Poly(ε-caprolactone) Blends, Adv Mater Res 2011 266, 171-174

    Dong HQ, Li YY, Wen HY, Shi DL, Liu LJ, Supramolecular Polymer Micelles Self-assembled from α-Cyclodextrin and PLLA-PCL Based Copolymers, J Control Release 2011, 152(1), E52-E54.

    Cai XJ, Dong HQ*, Xia WJ, Wen HY, Li XQ, Yu JH, Li YY, Shi DL, Glutathione-mediated Shedding of PEG Layers Based on Disulfide-Linked Catiomers for DNA Delivery, J Mater Chem 2011,21(38),14639-14645 (影响因子:6.1)

    Dong HQ, Zhao ZL, Wen HY, Li YY*, Guo FF, Shen AJ, Pilger F, Lin C, Shi DL*. Poly(ethylene glycol) Conjugated Nano-graphene Oxide for Photodynamic Therapy, Sci China Ser B, 2010, 53(11), 2265-2271.

     Wang K, Dong HQ, Wen HY, Xu M, Li C, Li YY*, Jones HN, Shi DL, Zhang XZ*. Novel Vesicles Self-assembled from Amphiphilic Star-armed PEG-Polypeptide Hybrid Copolymers for Drug Delivery. Macromol Biosci 2010,11, 65-71.

    Dong HQ, Li YY, Cai SJ, Zhang XZ, Liu LJ. A Facile One-Pot Construction of Supramolecular Polymer Micelles from α-Cyclodextrin and Poly(ε-caprolactone),Angew Chem Int Edit 2008, 47, 5573 –5576. (影响因子:13.734)

    Dong HQ, Xu Q, Li YY, Mo SB, Cai SJ, Liu LJ. The Synthesis of Biodegradable Graft Copolymer Cellulose-graft-Poly(L-lactide) and the Study of its Controlled Drug Release, Colloid Surface B 2008, 66, 26-33. (影响因子:3.5)

    刘立建,* 董海青, 一种超分子聚合物胶束及其制备方法, 申请号:200810048268.7 授权号:101298504B (法律状态公告日:2011.01.05)

    董海青, 李永勇,徐梦,赵志磊,时东陆, 一种超分子聚合物胶束的制备方法, 申请号:201010176116.2,公开号:ZL 201210245010,授权号:102241825B (法律状态公告日:2013. 2.13)

    董海青, 李永勇, 徐梦, 沈爱军, 温慧云, 时东陆, 用于光动力治疗的纳米氧化石墨烯载体的制备方法,申请号:201010252761.8 公开号: CN102370980A

    李永勇, 董海青, 徐梦, 时东陆, 对氨基酸敏感的超分子聚合物胶束药物载体的制备方法,申请号:201010281371.3公开号:CN102399369A 授权号:102399369B (法律状态公告日:2013.12.4)


董海青

董海青.jpg

董海青 博士

副研究员

同济大学生物医学工程与纳米科学研究院

地址:上海杨浦区赤峰路67号

邮编:200092

电话:+086-021-65983706-805

Email: inano_donghq@tongji.edu.cn

 

教育背景:

2004~2009年: 硕、博连读(公费生)武汉大学化学与分子科学学院

2000~2004年: 本科 黄冈师范学院化学系

 

工作经历:

2013~至今:副研究员 同济大学医学院 生物医学工程与纳米科学研究院

2011~2013:副研究员 同济大学转化医学高等研究院 时东陆课题组

2009~2011年:博士后 同济大学材料科学与工程博士后流动站

 

研究领域与兴趣:

1. 生物医用高分子及超分子自组装在生物医学及生物技术领域的应用

2. 多功能纳米药物载体在肿瘤治疗方面的应用研究

 

主持项目:

2013~2015年:上海市“晨光计划”:基于主客化学构建刺激响应纳米药物载体

2012~2014年:国家自然科学基金青年基金(21104059):超分子纳米胶束构建新策略及其药物控释应用研究

2010~2012年:中国博士后特别资助(201104268):药物分子调控的环糊精基超分子胶束的构建及其生物医用初探

2010~2011年:中国博士后基金(20100470111): 新型超分子聚合物胶束的设计与构建及其光动力治疗体外评价

2009~2011年:上海博士后基金(10R21415700):生物可降解超分子聚合物胶束的制备及其生物医学研究

 

代表性论文及专利:

    Liu QM,  Zhu HS, Qin JY,  Dong HQ*,  Du JZ*, Theranostic Vesicles Based on Bovine Serum Albumin and Poly(ethylene glycol)-block-poly(L‑lactic-co-glycolic acid) for Magnetic Resonance Imaging and Anticancer Drug Delivery, Biomacromolecules, 2014, 15, 1586-1592 (IF 5.783)

     Dong HQ,  Dong CY,  Li YY*,  Ren TB,  Shi DL*, Surface-Engineered Graphene-Based Nanomaterials for Drug Delivery,J Biomed Nanotech, 2014, 10, 2086-2106. (IF 7.578)

    Dong HQ, Dong CY, Xia WJ, Li YY, Ren TB, Self-assembled, Redox-sensitive, H-shaped Pegylated Methotrexate Conjugates with High Drug-carrying Capability for Intracellular Drug Delivery, MedChem Comm, 2014, 5, 147-152.

    Dong HQ, Li YY*, Yu JH, Song YY, Cai XJ, Liu JQ, Zhang JM, Ewing RC, Shi DL*, A Versatile Multi-Component Assembly via β-cyclodextrin Host-Guest Chemistry on Graphene for Biomedical Applications, Small 2013, 9(3), 446-456. (影响因子:8.349)

    Cai XJ, Dong HQ, Ma JP, Zhu HY, Wu W, Chu M, Li YY*, Shi DL*, Effects of spatial distribution of the nuclear localization sequence on gene transfection in catiomer–gene polyplexes, J Mater Chem B 2013,1, 1712-1721

    Dong HQ, Dong CY, Feng Y, Ren TB*, Zhang ZH, Li L, Li YY, Engineering of Peglayted Camptothecin into Core-shell Nanomicelles for Improving Solubility, Stability and Combination Delivery, MedChem Comm 2012, 3 (12), 1555-1561.

    Hu HQ, Yu JH, Li YY*, Zhao J, Dong HQ*, Engineering of a Novel Pluronic F127/Graphene Nanohybrid for pH Responsive Drug Delivery, J Biomed Mater Res A 2012, 100A, 141-148.

    Dong HQ, Li YY, Wen HY, Xu M, Liu LJ, Li ZQ, Guo FF, Shi DL, Highly Efficient Drug Delivery Nanosystem by L-Phenylalanine Triggering Based on Supramolecular Polymer Micelles, Macromol Rapid Comm 2011, 32(6), 540-545. (影响因子:4.9)

    Dong HQ, Li YY, Shi DL, Cyclodextrins/Polymer Based (Pseudo)Polyrotaxanes for Biomedical Application, Prog Chem 2011,23 (5): 914-922.

    Dong HQ, Liu LJ, Li YY, Shape Memory Behavior of Poly(L-lactide)/Poly(ε-caprolactone) Blends, Adv Mater Res 2011 266, 171-174

    Dong HQ, Li YY, Wen HY, Shi DL, Liu LJ, Supramolecular Polymer Micelles Self-assembled from α-Cyclodextrin and PLLA-PCL Based Copolymers, J Control Release 2011, 152(1), E52-E54.

    Cai XJ, Dong HQ*, Xia WJ, Wen HY, Li XQ, Yu JH, Li YY, Shi DL, Glutathione-mediated Shedding of PEG Layers Based on Disulfide-Linked Catiomers for DNA Delivery, J Mater Chem 2011,21(38),14639-14645 (影响因子:6.1)

    Dong HQ, Zhao ZL, Wen HY, Li YY*, Guo FF, Shen AJ, Pilger F, Lin C, Shi DL*. Poly(ethylene glycol) Conjugated Nano-graphene Oxide for Photodynamic Therapy, Sci China Ser B, 2010, 53(11), 2265-2271.

     Wang K, Dong HQ, Wen HY, Xu M, Li C, Li YY*, Jones HN, Shi DL, Zhang XZ*. Novel Vesicles Self-assembled from Amphiphilic Star-armed PEG-Polypeptide Hybrid Copolymers for Drug Delivery. Macromol Biosci 2010,11, 65-71.

    Dong HQ, Li YY, Cai SJ, Zhang XZ, Liu LJ. A Facile One-Pot Construction of Supramolecular Polymer Micelles from α-Cyclodextrin and Poly(ε-caprolactone),Angew Chem Int Edit 2008, 47, 5573 –5576. (影响因子:13.734)

    Dong HQ, Xu Q, Li YY, Mo SB, Cai SJ, Liu LJ. The Synthesis of Biodegradable Graft Copolymer Cellulose-graft-Poly(L-lactide) and the Study of its Controlled Drug Release, Colloid Surface B 2008, 66, 26-33. (影响因子:3.5)

    刘立建,* 董海青, 一种超分子聚合物胶束及其制备方法, 申请号:200810048268.7 授权号:101298504B (法律状态公告日:2011.01.05)

    董海青, 李永勇,徐梦,赵志磊,时东陆, 一种超分子聚合物胶束的制备方法, 申请号:201010176116.2,公开号:ZL 201210245010,授权号:102241825B (法律状态公告日:2013. 2.13)

    董海青, 李永勇, 徐梦, 沈爱军, 温慧云, 时东陆, 用于光动力治疗的纳米氧化石墨烯载体的制备方法,申请号:201010252761.8 公开号: CN102370980A

    李永勇, 董海青, 徐梦, 时东陆, 对氨基酸敏感的超分子聚合物胶束药物载体的制备方法,申请号:201010281371.3公开号:CN102399369A 授权号:102399369B (法律状态公告日:2013.12.4)


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