上海东方医院

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张兵波

张兵波.jpg

张兵波 博士

副研究员

博士生导师

同济大学生物医学工程与纳米科学研究院

地址:上海市杨浦区赤峰路67号

邮编:200092

电话:+086-021-65983706-805

Email: bingbozhang@tongji.edu.cn

 

教育背景:

2006-2009.3   天津大学材料学院,工学博士

2004- 2006     天津大学材料学院,工学硕士

2000- 2004     苏州大学材料学院,本科

 

工作经历:

2009.6-2012.11 助理研究员     同济大学

2012.12- 至今 副研究员         同济大学

 

研究领域:

(1) 新型分子影像探针

张兵波课题组长期致力于多模态纳米探针及诊疗一体化纳米技术的研究,特别是在荧光量子点探针合成、修饰及活体成像方面开展了系统的研究工作。迄今以第一作者和通讯作者身份在纳米生物医学领域共发表SCI论文27篇,其中在纳米影像领域发表SCI论文15余篇;H-index为13(仅计算第一与通讯作者论文)。2014年应World Scientific publisher邀请,作为主编筹备编写“Nano imaging: From Fundamental Principles to Practical Applications”一书,预计2015年9月出版。近三年来一直从事纳米探针的绿色可控合成,特别是基于蛋白、多肽仿生矿化合成荧光、CT、MR成像以及双模态探针上具有较丰富的研究经验。

(2) 体外分子诊断

本课题组注重纳米材料的生物医学应用,且已在这个方面做了大量的研究工作。在体外诊断方面,利用自行合成的纳米材料,经表面工程化修饰,标记相应的抗体分子,对体外血清,尿液等进行特异性,超灵敏检测。利用荧光量子点标记AFP单克隆抗体,结合免疫层析试纸条技术,对1000 例临床血样进行了AFP蛋白的快速、灵敏检测(Biosensors & bioelectronics,2011,30, 145-150);基于量子点具有一元激发多元发射的独特性质,利用自制的多色量子点经行了高通量检测的验证。基于液相生物芯片技术,采用自制的量子点荧光探针和聚苯乙烯微球,对甲胎蛋白(AFP)进行了检测。

 

荣誉与获奖:

中国光学会生物医学光子学专委会全国青年委员 (2015)

中国生物医学工程学会纳米医学分会全国青年委员 (2015)

同济大学青年英才骨干教师 (2013)

上海市“大学生创新活动计划项目”指导教师 (2012)

同济大学青年英才优秀教师 (2011)

同济大学优秀青年教师培养对象 (2009)

 

主持课题:

完成及在研主持项目有:国家自然科学基金,上海市教委创新重点项目,同济大学优秀青年培养计划项目,同济大学英才计划(优秀教师)项目,中央高校基本科研业务费专项资助基金和多项国家及教育部重点实验室研究基金等。

 

参与课题:

国家自然科学基金面上项目,科技部863项目和上海市纳米专项等。

 

代表性论文:

 

Tongji University

 

21.   Xing, X. H.; Zhang, B. B.*(通讯作者); Wang, X. H.; Liu, F. J.; Shi, D. L.; Cheng, Y. S.*, An "imaging-biopsy" strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials 2015, 48, 16-25. SCI, IF 8.312

20.   Guo, W. S.; Yang, W. T.; Wang, Y.; Sun, X. L.; Liu, Z. Y.; Zhang, B. B. *(通讯作者); Chang, J.*; Chen, X. Y.*, Color-tunable Gd-Zn-Cu-In-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging. Nano Res 2014, 7 (11), 1581-1591. SCI, IF 6.963

19.   Wang, X. H.; Xing, X. H.; Zhang, B. B. *(通讯作者); Liu, F. J.; Cheng, Y. S.*; Shi, D. L., Surface engineered antifouling optomagnetic SPIONs for bimodal targeted imaging of pancreatic cancer cells. International journal of nanomedicine 2014, 9, 1601-1615. SCI, IF 4.195

18.   Dai, L. L.; Liu, Y. K.; Wang, Z. Q.*; Guo, F. F.; Shi, D. L.; Zhang, B. B. *(通讯作者), One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement. Mat Sci Eng C-Mater 2014, 41, 161-167. SCI, IF 2.736

17.   Jin, H. T.; Liu, S. Y.*; Guo, F. F.; Zhang, B. B. *(通讯作者), Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicity Evaluation for MRI in Mice. J Biomater Tiss Eng 2014, 4 (6), 443-449. SCI, IF 1.167

16.   Yang, W. T.; Guo, W. S.; Zhang, B. B. *(通讯作者); Chang, J.*, Synthesis of Noble Metal Nanoclusters Based on Protein and Peptide as a Template. Acta Chim Sinica 2014, 72 (12), 1209-1217. SCI, IF 0.874

15.   Yang, Q. H.; Wang, X.; Yang, J. M.; Li, X.; Song, T.; Gong, X. Q.; Zhang, B. B. *(通讯作者); Chang, J.*, Development of Quantum Dot-Based Lateral Flow Immunoassay System for Rapid Quantitative Detection of Human Chorionic Gonadotropin. Prog Biochem Biophys 2014, 41 (5), 497-507. SCI, IF 0.29

14.   Guo, W. S.; Chen, N.; Tu, Y.; Dong, C. H.; Zhang, B. B. *(通讯作者); Hu, C. H.; Chang, J.*, Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging. Theranostics 2013, 3 (2), 99-108. SCI, IF 7.827

13.   Wang, Y.; Ji, L.; Zhang, B. B. *(通讯作者); Yin, P. H.; Qiu, Y. Y.; Song, D. Q.; Zhou, J. Y.; Li, Q.*, Upconverting rare-earth nanoparticles with a paramagnetic lanthanide complex shell for upconversion fluorescent and magnetic resonance dual-modality imaging. Nanotechnology 2013, 24 (17). SCI, IF 3.672

12.   Guo, W. S.; Chen, N.; Dong, C. H.; Tu, Y.; Chang, J.*; Zhang, B. B. *(通讯作者), One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging. Rsc Adv 2013, 3 (24), 9470-9475. SCI, IF 3.708

11.   Li, Y.; Li, Z.; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Zhang, B. B. *(通讯作者); Shi, D. L., In Vivo Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates. Theranostics 2012, 2 (8), 769-776. SCI, IF 7.827

10.   Zhang, B. B.*; Jin, H. T.; Li, Y.; Chen, B. D.; Liu, S. Y.; Shi, D. L., Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. J Mater Chem 2012, 22 (29), 14494-14501. SCI, IF 6.626

9.      Zhang, B. B.*; Li, Q.; Yin, P. H.; Rui, Y. P.; Qiu, Y. Y.; Wang, Y.; Shi, D. L., Ultrasound-Triggered BSA/SPION Hybrid Nanoclusters for Liver-Specific Magnetic Resonance Imaging. Acs Appl Mater Inter 2012, 4 (12), 6479-6486. SCI, IF 5.9

8.      Zhang, B. B.*; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Shi, D. L., Effective Reduction of Nonspecific Binding by Surface Engineering of Quantum Dots with Bovine Serum Albumin for Cell-Targeted Imaging. Langmuir 2012, 28 (48), 16605-16613. SCI, IF 4.384

7.      Zhang, A. L.; Tu, Y.; Qin, S. B.; Li, Y.; Zhou, J. Y.; Chen, N.; Lu, Q.; Zhang, B. B. *(通讯作者), Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging. J Colloid Interf Sci 2012, 372, 239-244. SCI, IF 3.552

6.      Liu, F. J.; Zhang, B. B. *(通讯作者); Song, G.; Cheng, Y. S.*, Gd3+ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells. Chem J Chinese U 2012, 33 (2), 378-382. SCI, IF 0.954

5.      Kong, J.; Qiu, H.; Yu, M.; Zhang, B. B. *(通讯作者), Effect of Structure on the Fluorescent Properties of the Hydrophilic Modified Quantum Dots. Acta Chim Sinica 2012, 70 (6), 789-795. SCI, IF 0.874

4.      Yang, Q. H.; Gong, X. Q.; Song, T.; Yang, J. M.; Zhu, S. J.; Li, Y. H.; Cui, Y.; Li, Y. X.; Zhang, B. B. *(通讯作者); Chang, J.*, Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein. Biosens Bioelectron 2011, 30 (1), 145-150. SCI, IF 6.451

3.      Zhang, B. B.*; Chen, B. D.; Wang, Y. L.; Guo, F. F.; Li, Z. Q.; Shi, D. L., Preparation of highly fluorescent magnetic nanoparticles for analytes-enrichment and subsequent biodetection. J Colloid Interf Sci 2011, 353 (2), 426-432. SCI, IF 3.552

2.      Zhang, B. B.; Xing, D.; Lin, C.; Guo, F. F.; Zhao, P.; Wen, X. J.; Bao, Z. H.*; Shi, D. L., Improving colloidal properties of quantum dots with combined silica and polymer coatings for in vitro immuofluorenscence assay. J Nanopart Res 2011, 13 (6), 2407-2415. SCI, IF 2.278

1.      Zhang, B. B.; Gong, X. Q.; Li, Z. Q.; Guo, F. F.; Cai, S. Y.; Kong, J. L.; Yang, Q. H.; Ma, H.; Chang, J.; Shi, D. L.*, Preparation of Gd-III/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis. Chem J Chinese U 2010, 31 (5), 982-985. SCI, IF 0.954

 

Tianjin University

 

6.      Zhang, B. B.; Liang, X. F.; Hao, L. J.; Cheng, J.; Gong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Quantum dots /particle-based immunofluorescence assay: Synthesis, characterization and application. J Photoch Photobio B 2009, 94 (1), 45-50.  SCI, IF 2.803

5.      Zhang, B. B.; Gong, X. Q.; Lin, T. T.; He, Y. J.; Cheng, J.; Shan, S. Y.; Chang, J., Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO2 with Amino Groups. Chem J Chinese U 2009, 30 (2), 246-249. SCI, IF 0.954

4.      Zhang, B. B.; Liu, X. H.; Li, D. N.; Tian, H.; Ma, G. P.; Chang, J.*, Preparation of multi-color quantum dots and its application to immunohistochemical analysis. Chinese Sci Bull 2008, 53 (13), 2077-2083.  SCI, IF 1.365

3.      Zhang, B. B.; Gong, X. Q.; Hao, L. J.; Cheng, J.; Han, Y.; Chang, J.*, A novel method to enhance quantum yield of silica-coated quantum dots for biodetection. Nanotechnology 2008, 19 (46).  SCI, IF 3.672

2.      Zhang, B. B.; Cheng, J.; Li, D. N.; Liu, X. H.; Ma, G. P.; Chang, J.*, A novel method to make hydrophilic quantum dots and its application on biodetection. Mater Sci Eng B-Adv 2008, 149 (1), 87-92.  SCI, IF 2.122

1.      Zhang, B. B.; Cheng, J.; Gong, X. Q.; Dong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Facile fabrication of multi-colors high fluorescent/superparamagnetic nanoparticles. J Colloid Interf Sci 2008, 322 (2), 485-490.  SCI, IF 3.552

 

主要学术会议:

1. Nano Imaging: From Probe Design, Synthesis to Translational Medical Applications, 2015 International Molecular Imaging Summit, Xiamen, China, Oct.2015.(Oral Presentation)

2. Protein/Peptide-Mediated Biomineralization of Nanoprobes for Biomedical Theranostics, Academic Seminar on the Establishment of Nano Medicine and Engineering Branch in Chinese Society of Biomedical Engineering (CSBE), Suzhou, China, July, 2015.(Oral Presentation)

3. Gadolinium‐Functionalized Quantum Trigons for Targeted Tumor MR Imaging and Molecular Profiling, The 8th International Conference on Advanced Materials Processing, Gold Coast, QLD, Australia, July, 2014. (Oral Presentation)

4. Nano-based Magnetic Resonance Imaging: From the Probe Preparation, Surface Modification to the Tumor Imaging, The Sixth National Low Field Nuclear Magnetic Resonance (NMR) Technology and its Application Workshop, Hangzhou, China, Oct. 2014.(Oral Presentation)

5. A Novel MRI/Fluorescent Bimodal Nanoprobe for Pancreatic Cancer Detection, The 14th Chinese Biomaterials Congress, Xi’an, China, Sept. 2013.(Oral Presentation)

 

专利:

1. 张兵波、王祎龙、赵鹏、郭方方、时东陆。“一种防功能性物质泄漏的核壳微/纳米球的制备方法” 申请号:200910198674.6

2. 常 津, 马贵平, 张兵波等.  油溶性量子点水溶性改性方法. 公开号:CN101012373A

3. 马贵平,刘旭辉,常津,张兵波等. H5N1型高致病性禽流感的纳米量子点检测方法. 申请号:200710065554.X

张兵波

张兵波.jpg

张兵波 博士

副研究员

博士生导师

同济大学生物医学工程与纳米科学研究院

地址:上海市杨浦区赤峰路67号

邮编:200092

电话:+086-021-65983706-805

Email: bingbozhang@tongji.edu.cn

 

教育背景:

2006-2009.3   天津大学材料学院,工学博士

2004- 2006     天津大学材料学院,工学硕士

2000- 2004     苏州大学材料学院,本科

 

工作经历:

2009.6-2012.11 助理研究员     同济大学

2012.12- 至今 副研究员         同济大学

 

研究领域:

(1) 新型分子影像探针

张兵波课题组长期致力于多模态纳米探针及诊疗一体化纳米技术的研究,特别是在荧光量子点探针合成、修饰及活体成像方面开展了系统的研究工作。迄今以第一作者和通讯作者身份在纳米生物医学领域共发表SCI论文27篇,其中在纳米影像领域发表SCI论文15余篇;H-index为13(仅计算第一与通讯作者论文)。2014年应World Scientific publisher邀请,作为主编筹备编写“Nano imaging: From Fundamental Principles to Practical Applications”一书,预计2015年9月出版。近三年来一直从事纳米探针的绿色可控合成,特别是基于蛋白、多肽仿生矿化合成荧光、CT、MR成像以及双模态探针上具有较丰富的研究经验。

(2) 体外分子诊断

本课题组注重纳米材料的生物医学应用,且已在这个方面做了大量的研究工作。在体外诊断方面,利用自行合成的纳米材料,经表面工程化修饰,标记相应的抗体分子,对体外血清,尿液等进行特异性,超灵敏检测。利用荧光量子点标记AFP单克隆抗体,结合免疫层析试纸条技术,对1000 例临床血样进行了AFP蛋白的快速、灵敏检测(Biosensors & bioelectronics,2011,30, 145-150);基于量子点具有一元激发多元发射的独特性质,利用自制的多色量子点经行了高通量检测的验证。基于液相生物芯片技术,采用自制的量子点荧光探针和聚苯乙烯微球,对甲胎蛋白(AFP)进行了检测。

 

荣誉与获奖:

中国光学会生物医学光子学专委会全国青年委员 (2015)

中国生物医学工程学会纳米医学分会全国青年委员 (2015)

同济大学青年英才骨干教师 (2013)

上海市“大学生创新活动计划项目”指导教师 (2012)

同济大学青年英才优秀教师 (2011)

同济大学优秀青年教师培养对象 (2009)

 

主持课题:

完成及在研主持项目有:国家自然科学基金,上海市教委创新重点项目,同济大学优秀青年培养计划项目,同济大学英才计划(优秀教师)项目,中央高校基本科研业务费专项资助基金和多项国家及教育部重点实验室研究基金等。

 

参与课题:

国家自然科学基金面上项目,科技部863项目和上海市纳米专项等。

 

代表性论文:

 

Tongji University

 

21.   Xing, X. H.; Zhang, B. B.*(通讯作者); Wang, X. H.; Liu, F. J.; Shi, D. L.; Cheng, Y. S.*, An "imaging-biopsy" strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials 2015, 48, 16-25. SCI, IF 8.312

20.   Guo, W. S.; Yang, W. T.; Wang, Y.; Sun, X. L.; Liu, Z. Y.; Zhang, B. B. *(通讯作者); Chang, J.*; Chen, X. Y.*, Color-tunable Gd-Zn-Cu-In-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging. Nano Res 2014, 7 (11), 1581-1591. SCI, IF 6.963

19.   Wang, X. H.; Xing, X. H.; Zhang, B. B. *(通讯作者); Liu, F. J.; Cheng, Y. S.*; Shi, D. L., Surface engineered antifouling optomagnetic SPIONs for bimodal targeted imaging of pancreatic cancer cells. International journal of nanomedicine 2014, 9, 1601-1615. SCI, IF 4.195

18.   Dai, L. L.; Liu, Y. K.; Wang, Z. Q.*; Guo, F. F.; Shi, D. L.; Zhang, B. B. *(通讯作者), One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement. Mat Sci Eng C-Mater 2014, 41, 161-167. SCI, IF 2.736

17.   Jin, H. T.; Liu, S. Y.*; Guo, F. F.; Zhang, B. B. *(通讯作者), Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicity Evaluation for MRI in Mice. J Biomater Tiss Eng 2014, 4 (6), 443-449. SCI, IF 1.167

16.   Yang, W. T.; Guo, W. S.; Zhang, B. B. *(通讯作者); Chang, J.*, Synthesis of Noble Metal Nanoclusters Based on Protein and Peptide as a Template. Acta Chim Sinica 2014, 72 (12), 1209-1217. SCI, IF 0.874

15.   Yang, Q. H.; Wang, X.; Yang, J. M.; Li, X.; Song, T.; Gong, X. Q.; Zhang, B. B. *(通讯作者); Chang, J.*, Development of Quantum Dot-Based Lateral Flow Immunoassay System for Rapid Quantitative Detection of Human Chorionic Gonadotropin. Prog Biochem Biophys 2014, 41 (5), 497-507. SCI, IF 0.29

14.   Guo, W. S.; Chen, N.; Tu, Y.; Dong, C. H.; Zhang, B. B. *(通讯作者); Hu, C. H.; Chang, J.*, Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging. Theranostics 2013, 3 (2), 99-108. SCI, IF 7.827

13.   Wang, Y.; Ji, L.; Zhang, B. B. *(通讯作者); Yin, P. H.; Qiu, Y. Y.; Song, D. Q.; Zhou, J. Y.; Li, Q.*, Upconverting rare-earth nanoparticles with a paramagnetic lanthanide complex shell for upconversion fluorescent and magnetic resonance dual-modality imaging. Nanotechnology 2013, 24 (17). SCI, IF 3.672

12.   Guo, W. S.; Chen, N.; Dong, C. H.; Tu, Y.; Chang, J.*; Zhang, B. B. *(通讯作者), One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging. Rsc Adv 2013, 3 (24), 9470-9475. SCI, IF 3.708

11.   Li, Y.; Li, Z.; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Zhang, B. B. *(通讯作者); Shi, D. L., In Vivo Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates. Theranostics 2012, 2 (8), 769-776. SCI, IF 7.827

10.   Zhang, B. B.*; Jin, H. T.; Li, Y.; Chen, B. D.; Liu, S. Y.; Shi, D. L., Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. J Mater Chem 2012, 22 (29), 14494-14501. SCI, IF 6.626

9.      Zhang, B. B.*; Li, Q.; Yin, P. H.; Rui, Y. P.; Qiu, Y. Y.; Wang, Y.; Shi, D. L., Ultrasound-Triggered BSA/SPION Hybrid Nanoclusters for Liver-Specific Magnetic Resonance Imaging. Acs Appl Mater Inter 2012, 4 (12), 6479-6486. SCI, IF 5.9

8.      Zhang, B. B.*; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Shi, D. L., Effective Reduction of Nonspecific Binding by Surface Engineering of Quantum Dots with Bovine Serum Albumin for Cell-Targeted Imaging. Langmuir 2012, 28 (48), 16605-16613. SCI, IF 4.384

7.      Zhang, A. L.; Tu, Y.; Qin, S. B.; Li, Y.; Zhou, J. Y.; Chen, N.; Lu, Q.; Zhang, B. B. *(通讯作者), Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging. J Colloid Interf Sci 2012, 372, 239-244. SCI, IF 3.552

6.      Liu, F. J.; Zhang, B. B. *(通讯作者); Song, G.; Cheng, Y. S.*, Gd3+ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells. Chem J Chinese U 2012, 33 (2), 378-382. SCI, IF 0.954

5.      Kong, J.; Qiu, H.; Yu, M.; Zhang, B. B. *(通讯作者), Effect of Structure on the Fluorescent Properties of the Hydrophilic Modified Quantum Dots. Acta Chim Sinica 2012, 70 (6), 789-795. SCI, IF 0.874

4.      Yang, Q. H.; Gong, X. Q.; Song, T.; Yang, J. M.; Zhu, S. J.; Li, Y. H.; Cui, Y.; Li, Y. X.; Zhang, B. B. *(通讯作者); Chang, J.*, Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein. Biosens Bioelectron 2011, 30 (1), 145-150. SCI, IF 6.451

3.      Zhang, B. B.*; Chen, B. D.; Wang, Y. L.; Guo, F. F.; Li, Z. Q.; Shi, D. L., Preparation of highly fluorescent magnetic nanoparticles for analytes-enrichment and subsequent biodetection. J Colloid Interf Sci 2011, 353 (2), 426-432. SCI, IF 3.552

2.      Zhang, B. B.; Xing, D.; Lin, C.; Guo, F. F.; Zhao, P.; Wen, X. J.; Bao, Z. H.*; Shi, D. L., Improving colloidal properties of quantum dots with combined silica and polymer coatings for in vitro immuofluorenscence assay. J Nanopart Res 2011, 13 (6), 2407-2415. SCI, IF 2.278

1.      Zhang, B. B.; Gong, X. Q.; Li, Z. Q.; Guo, F. F.; Cai, S. Y.; Kong, J. L.; Yang, Q. H.; Ma, H.; Chang, J.; Shi, D. L.*, Preparation of Gd-III/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis. Chem J Chinese U 2010, 31 (5), 982-985. SCI, IF 0.954

 

Tianjin University

 

6.      Zhang, B. B.; Liang, X. F.; Hao, L. J.; Cheng, J.; Gong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Quantum dots /particle-based immunofluorescence assay: Synthesis, characterization and application. J Photoch Photobio B 2009, 94 (1), 45-50.  SCI, IF 2.803

5.      Zhang, B. B.; Gong, X. Q.; Lin, T. T.; He, Y. J.; Cheng, J.; Shan, S. Y.; Chang, J., Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO2 with Amino Groups. Chem J Chinese U 2009, 30 (2), 246-249. SCI, IF 0.954

4.      Zhang, B. B.; Liu, X. H.; Li, D. N.; Tian, H.; Ma, G. P.; Chang, J.*, Preparation of multi-color quantum dots and its application to immunohistochemical analysis. Chinese Sci Bull 2008, 53 (13), 2077-2083.  SCI, IF 1.365

3.      Zhang, B. B.; Gong, X. Q.; Hao, L. J.; Cheng, J.; Han, Y.; Chang, J.*, A novel method to enhance quantum yield of silica-coated quantum dots for biodetection. Nanotechnology 2008, 19 (46).  SCI, IF 3.672

2.      Zhang, B. B.; Cheng, J.; Li, D. N.; Liu, X. H.; Ma, G. P.; Chang, J.*, A novel method to make hydrophilic quantum dots and its application on biodetection. Mater Sci Eng B-Adv 2008, 149 (1), 87-92.  SCI, IF 2.122

1.      Zhang, B. B.; Cheng, J.; Gong, X. Q.; Dong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Facile fabrication of multi-colors high fluorescent/superparamagnetic nanoparticles. J Colloid Interf Sci 2008, 322 (2), 485-490.  SCI, IF 3.552

 

主要学术会议:

1. Nano Imaging: From Probe Design, Synthesis to Translational Medical Applications, 2015 International Molecular Imaging Summit, Xiamen, China, Oct.2015.(Oral Presentation)

2. Protein/Peptide-Mediated Biomineralization of Nanoprobes for Biomedical Theranostics, Academic Seminar on the Establishment of Nano Medicine and Engineering Branch in Chinese Society of Biomedical Engineering (CSBE), Suzhou, China, July, 2015.(Oral Presentation)

3. Gadolinium‐Functionalized Quantum Trigons for Targeted Tumor MR Imaging and Molecular Profiling, The 8th International Conference on Advanced Materials Processing, Gold Coast, QLD, Australia, July, 2014. (Oral Presentation)

4. Nano-based Magnetic Resonance Imaging: From the Probe Preparation, Surface Modification to the Tumor Imaging, The Sixth National Low Field Nuclear Magnetic Resonance (NMR) Technology and its Application Workshop, Hangzhou, China, Oct. 2014.(Oral Presentation)

5. A Novel MRI/Fluorescent Bimodal Nanoprobe for Pancreatic Cancer Detection, The 14th Chinese Biomaterials Congress, Xi’an, China, Sept. 2013.(Oral Presentation)

 

专利:

1. 张兵波、王祎龙、赵鹏、郭方方、时东陆。“一种防功能性物质泄漏的核壳微/纳米球的制备方法” 申请号:200910198674.6

2. 常 津, 马贵平, 张兵波等.  油溶性量子点水溶性改性方法. 公开号:CN101012373A

3. 马贵平,刘旭辉,常津,张兵波等. H5N1型高致病性禽流感的纳米量子点检测方法. 申请号:200710065554.X

上海市东方医院 纳米医学应用技术研究所

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