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Zheng Cui, Ph.D.

崔征.jpg

Zheng Cui, MD., M.S., Ph.D.
                     
Tepin Professor of The Institute for Advanced Materials and Nano Biomedicine, Tongji University, China.
Tel: 86-21-6598-8029, Fax: 86-21-6598-8029

Department of Pathology Wake Forest University School of Medicine Medical Center Boulevard Winston-Salem, NC 27157, USA
zhengcui@wfubmc.edu; Zheng.cui@gmail.com


    EDUCATION

    1987-1990 Harvard Medical School/Biochemistry Harvard University Cambridge, Massachusetts

    1982-1988 University of Massachusetts Amherst, Massachusetts Ph.D. (Biochemistry

    1979-1981 Institute of Biochemistry/Entomology Academia Sinica Shanghai, China M.S. (Biochemistry)

    1976-1979 Zuenyi Medical College Zuenyi, Gueichou Province, China M.D.

 

    POSITIONS HELD

    2003-present  Tenured

    2002-present  Associate Professor Department of Pathology Wake Forest University School of Medicine Winston-Salem, North Carolina

    2002  Associate Professor Department of Biochemistry Wake Forest University School of Medicine Winston-Salem, North Carolina

    1996-2002 Assistant Professor Department of Biochemistry Wake Forest University School of Medicine Winston-Salem, North Carolina

    1990-1996 Research Associate Department of Biochemistry University of Alberta Edmonton, Canada


    PROFESSIONAL RECOGNITION

    INVITED GRANT REVIEWERS:

    Research Into Aging, London Austrian Science Fund USDOD

    EDITORIAL BOARD:

    2007-Present Research Letters in Biochemistry

    2004-Present Analytical Biochemistry

    JOURNAL REVIEW:

    Journal of Biological Chemistry

    FASEB Journal

    Biochemistry

    Lipids Biochemistry Biophysics Acta

    Analytical Biochemistry

    Analytical Chemistry

    Oncogene

    Cancer Immunology and Immunotherapy

    Journal of Lipid Research

    Expert opinions on biological therapies

    HONORS AND AWARDS:

    2001-2003 National Cancer Institute Shannon Award

    1989-1990 American Heart Association Postdoctoral Fellowship

 

    Biographical Sketch

    SELECTED PUBLICATIONS

    Chapters in Books:

    Vance DE, Cui Z, Houweling M, Walkey CJ, Tessitore L. Phosphatidylethanolamine N-methyltransferase: an unexpected regulator of hepatocyte cell division. In: Szuhai B, Zeisel S, eds. Choline, Phospholipids, Health and Diseases. Champaign, IL: AORS Press 1998: 23-29.

    Cui, Z. From animal model to new drug discovery. In: A textbook of fundamental medical pharmacology. Lin, Y. and Li, S.N. eds., Jilin, China: Jilin Science and Technology Publishing House, 2004: 54-59

    Cui, Z. Chapter 9: Near Term Prospects for Broad Spectrum Amelioration of Cancer. In: The Future of Aging: Pathways to Human Life Extension. Fahy, G.M.; West, M.D.; Coles, L.S.; Harris, S.B. (Eds.), Springer 2010

 

    Research Articles:

    Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham and Zheng Cui, The Spectrum of Resistance in SR/CR Mice: the Critical Role of Chemoattraction in the Cancer/Leukocyte Interaction. BMC Cancer. 2010 April, [Epub ahead of print]

    Sanders AM, Stehle JR Jr, Blanks MJ, Riedlinger G, Kim-Shapiro JW, Monjazeb AM, Adams JM, Willingham MC, Cui Z. Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements. BMC Cancer. 2010 Mar 31;10(1):121.

    Stehle JR Jr, Blanks MJ, Riedlinger G, Kim-Shapiro JW, Sanders AM, Adams JM, Willingham MC, Cui Z. Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice. BMC Cancer. 2009 Sep 15; 9:328.

    Du W, Cui Z, Tsui ZC, Chen Q, Willingham MC. In situ immunocytochemical detection of altered membrane composition induced by cell-cell contact in cultured mammalian cells. Microsc Res Tech. 2008 Oct;71(10):749-59.

    Li J, Cui Z, Zhao S, Sidman RL. (2007) Unique Glycerophospholipid Signature in Retinal Stem Cells Correlates with Enzymatic Functions of Diverse Long-chain Acyl-CoA Synthetases. Stem Cells. 25(11):2864-73. [Epub 2007 Aug 9]

    Stehle JR Jr, Weeks ME, Lin K, Willingham MC, Hicks AM, Timms JF, Cui Z. (2007) Mass spectrometry identification of circulating alpha-1-B glycoprotein, increased in aged female C57BL/6 mice. Biochim Biophys Acta. 1770:79-86 (epub Jul 25, 2006)

    Amy M. Hicks, Mark C. Willingham, Wei Du, ChangLee Pang, Lloyd J. Old, Zheng Cui (2006) Effector mechanisms for anti-cancer immune response of macrophages in SR/CR mice. Cancer Immunity 6:11-18

    Hicks AM, Delong CJ, Thomas MJ, Samuel M, Cui Z. (2006) Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. Biochim Biophys Acta. 1761:1022-1029, (epub Jun 2, 2006).

    Tran, K., Sun, F., Cui, Z., Thorne-Tjomsland, G., St.Germain, C., Lapierre, L.R., McLeod, R.S., Jamieson, J.C., Yao, Z. (2006) Attenuated secretion of very low density lipoproteins form McA-RH7777 cells treated with eicosapentaenoic acid is associated with impaired utilization of triacylglycerol synthesized via phospholipids remodeling. Biochim Biophys Acta 1761:463-473, (epub Mar 29, 2006)

    Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7753-8. Epub 2006 May 8.

    Bleijerveld OB, Houweling M, Thomas MJ, Cui Z. Metabolipidomics: profiling metabolism of glycerophospholipid species by stable isotopic precursors and tandem mass spectrometry. Anal Biochem. 2006 May 1;352(1):1-14. Epub 2006 Mar 10.

    Stehle JR Jr, Willingham MC, Lin K, Cui Z. A nonterminal method for frequent collection of mouse circulating proteins by peritoneal lavage. Anal Biochem. 2006 Feb 1;349(1):162-4. Epub 2005 Nov 9.

    ZC Tsui, QR Chen, MJ Thomas, M Samuel, Z Cui, A method for profiling gangliosides in animal tissues using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). (2005) Analytical Biochem. 341:251-258.

    Y Shen, CJ DeLong, F Terce, T Kute, MC Willingham, M Pettenati, Z Cui, Polyploid formation via chromosome duplication induced by CTP: phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression. (2005) Journal of Cytochemistry and Histochemistry, 53(6): 725-33.

    Cui Z, Willingham M. Halo naevus: a visible case of immunosurveillance in humans? Lancet 2004; 5:397-398.

    Cui Z. The winding road to the discovery of the SR/CR mice. Cancer Immunity 2003; 3:14.

    Cui Z, Willingham MC. The effect of aging on innate cellular immunity against cancer. Cancer Immunol Immunotherapies 2004; 53:473-478.

    Zhang H, Links PH, Ngsee JK, Tran K, Cui Z, Ko KWS, Yao Z. Localization of LDL receptor-related protein 1 (LRP1) to caveolae in 3T3-L1 adipocytes in response to insulin treatment. J Biol Chem 2004; 279:2221-2230.

    Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci USA 2003; 100:6682-6687.

    Cui Z, Houweling M. Phosphatidylcholine and cell death. Biochem Biophys Acta 2002; 1585:87-96.

    Tran K, Thorne-Tjomsland G, DeLong C, Cui Z, Shan J, Burton L, Jamieson JC, Yao Z. Intracellular assembly of very low density lipoprotein in rat hepatoma McA-RH777 cells. J Biol Chem 2002; 277:31187-31200.

    DeLong CJ, Hicks AM, Cui Z. Disruption of choline methely group donation for phosphati-dylethanolamine methylation in hepatocarcinoma cells. J Biol Chem 2002; 277:17217-17225.

    DeLong CJ, Baker P, Samuel M, Cui Z, Thomas MJ. Molecular species composition of rat liver phospholipids by ESI-MS/MS: the effect of chromatography. J Lipid Res 2001; 42:1959-1968.


Zheng Cui, Ph.D.

崔征.jpg

Zheng Cui, MD., M.S., Ph.D.
                     
Tepin Professor of The Institute for Advanced Materials and Nano Biomedicine, Tongji University, China.
Tel: 86-21-6598-8029, Fax: 86-21-6598-8029

Department of Pathology Wake Forest University School of Medicine Medical Center Boulevard Winston-Salem, NC 27157, USA
zhengcui@wfubmc.edu; Zheng.cui@gmail.com


    EDUCATION

    1987-1990 Harvard Medical School/Biochemistry Harvard University Cambridge, Massachusetts

    1982-1988 University of Massachusetts Amherst, Massachusetts Ph.D. (Biochemistry

    1979-1981 Institute of Biochemistry/Entomology Academia Sinica Shanghai, China M.S. (Biochemistry)

    1976-1979 Zuenyi Medical College Zuenyi, Gueichou Province, China M.D.

 

    POSITIONS HELD

    2003-present  Tenured

    2002-present  Associate Professor Department of Pathology Wake Forest University School of Medicine Winston-Salem, North Carolina

    2002  Associate Professor Department of Biochemistry Wake Forest University School of Medicine Winston-Salem, North Carolina

    1996-2002 Assistant Professor Department of Biochemistry Wake Forest University School of Medicine Winston-Salem, North Carolina

    1990-1996 Research Associate Department of Biochemistry University of Alberta Edmonton, Canada


    PROFESSIONAL RECOGNITION

    INVITED GRANT REVIEWERS:

    Research Into Aging, London Austrian Science Fund USDOD

    EDITORIAL BOARD:

    2007-Present Research Letters in Biochemistry

    2004-Present Analytical Biochemistry

    JOURNAL REVIEW:

    Journal of Biological Chemistry

    FASEB Journal

    Biochemistry

    Lipids Biochemistry Biophysics Acta

    Analytical Biochemistry

    Analytical Chemistry

    Oncogene

    Cancer Immunology and Immunotherapy

    Journal of Lipid Research

    Expert opinions on biological therapies

    HONORS AND AWARDS:

    2001-2003 National Cancer Institute Shannon Award

    1989-1990 American Heart Association Postdoctoral Fellowship

 

    Biographical Sketch

    SELECTED PUBLICATIONS

    Chapters in Books:

    Vance DE, Cui Z, Houweling M, Walkey CJ, Tessitore L. Phosphatidylethanolamine N-methyltransferase: an unexpected regulator of hepatocyte cell division. In: Szuhai B, Zeisel S, eds. Choline, Phospholipids, Health and Diseases. Champaign, IL: AORS Press 1998: 23-29.

    Cui, Z. From animal model to new drug discovery. In: A textbook of fundamental medical pharmacology. Lin, Y. and Li, S.N. eds., Jilin, China: Jilin Science and Technology Publishing House, 2004: 54-59

    Cui, Z. Chapter 9: Near Term Prospects for Broad Spectrum Amelioration of Cancer. In: The Future of Aging: Pathways to Human Life Extension. Fahy, G.M.; West, M.D.; Coles, L.S.; Harris, S.B. (Eds.), Springer 2010

 

    Research Articles:

    Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham and Zheng Cui, The Spectrum of Resistance in SR/CR Mice: the Critical Role of Chemoattraction in the Cancer/Leukocyte Interaction. BMC Cancer. 2010 April, [Epub ahead of print]

    Sanders AM, Stehle JR Jr, Blanks MJ, Riedlinger G, Kim-Shapiro JW, Monjazeb AM, Adams JM, Willingham MC, Cui Z. Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements. BMC Cancer. 2010 Mar 31;10(1):121.

    Stehle JR Jr, Blanks MJ, Riedlinger G, Kim-Shapiro JW, Sanders AM, Adams JM, Willingham MC, Cui Z. Impact of sex, MHC, and age of recipients on the therapeutic effect of transferred leukocytes from cancer-resistant SR/CR mice. BMC Cancer. 2009 Sep 15; 9:328.

    Du W, Cui Z, Tsui ZC, Chen Q, Willingham MC. In situ immunocytochemical detection of altered membrane composition induced by cell-cell contact in cultured mammalian cells. Microsc Res Tech. 2008 Oct;71(10):749-59.

    Li J, Cui Z, Zhao S, Sidman RL. (2007) Unique Glycerophospholipid Signature in Retinal Stem Cells Correlates with Enzymatic Functions of Diverse Long-chain Acyl-CoA Synthetases. Stem Cells. 25(11):2864-73. [Epub 2007 Aug 9]

    Stehle JR Jr, Weeks ME, Lin K, Willingham MC, Hicks AM, Timms JF, Cui Z. (2007) Mass spectrometry identification of circulating alpha-1-B glycoprotein, increased in aged female C57BL/6 mice. Biochim Biophys Acta. 1770:79-86 (epub Jul 25, 2006)

    Amy M. Hicks, Mark C. Willingham, Wei Du, ChangLee Pang, Lloyd J. Old, Zheng Cui (2006) Effector mechanisms for anti-cancer immune response of macrophages in SR/CR mice. Cancer Immunity 6:11-18

    Hicks AM, Delong CJ, Thomas MJ, Samuel M, Cui Z. (2006) Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry. Biochim Biophys Acta. 1761:1022-1029, (epub Jun 2, 2006).

    Tran, K., Sun, F., Cui, Z., Thorne-Tjomsland, G., St.Germain, C., Lapierre, L.R., McLeod, R.S., Jamieson, J.C., Yao, Z. (2006) Attenuated secretion of very low density lipoproteins form McA-RH7777 cells treated with eicosapentaenoic acid is associated with impaired utilization of triacylglycerol synthesized via phospholipids remodeling. Biochim Biophys Acta 1761:463-473, (epub Mar 29, 2006)

    Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci U S A. 2006 May 16; 103(20): 7753-8. Epub 2006 May 8.

    Bleijerveld OB, Houweling M, Thomas MJ, Cui Z. Metabolipidomics: profiling metabolism of glycerophospholipid species by stable isotopic precursors and tandem mass spectrometry. Anal Biochem. 2006 May 1;352(1):1-14. Epub 2006 Mar 10.

    Stehle JR Jr, Willingham MC, Lin K, Cui Z. A nonterminal method for frequent collection of mouse circulating proteins by peritoneal lavage. Anal Biochem. 2006 Feb 1;349(1):162-4. Epub 2005 Nov 9.

    ZC Tsui, QR Chen, MJ Thomas, M Samuel, Z Cui, A method for profiling gangliosides in animal tissues using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). (2005) Analytical Biochem. 341:251-258.

    Y Shen, CJ DeLong, F Terce, T Kute, MC Willingham, M Pettenati, Z Cui, Polyploid formation via chromosome duplication induced by CTP: phosphocholine cytidylyltransferase deficiency and Bcl-2 overexpression. (2005) Journal of Cytochemistry and Histochemistry, 53(6): 725-33.

    Cui Z, Willingham M. Halo naevus: a visible case of immunosurveillance in humans? Lancet 2004; 5:397-398.

    Cui Z. The winding road to the discovery of the SR/CR mice. Cancer Immunity 2003; 3:14.

    Cui Z, Willingham MC. The effect of aging on innate cellular immunity against cancer. Cancer Immunol Immunotherapies 2004; 53:473-478.

    Zhang H, Links PH, Ngsee JK, Tran K, Cui Z, Ko KWS, Yao Z. Localization of LDL receptor-related protein 1 (LRP1) to caveolae in 3T3-L1 adipocytes in response to insulin treatment. J Biol Chem 2004; 279:2221-2230.

    Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci USA 2003; 100:6682-6687.

    Cui Z, Houweling M. Phosphatidylcholine and cell death. Biochem Biophys Acta 2002; 1585:87-96.

    Tran K, Thorne-Tjomsland G, DeLong C, Cui Z, Shan J, Burton L, Jamieson JC, Yao Z. Intracellular assembly of very low density lipoprotein in rat hepatoma McA-RH777 cells. J Biol Chem 2002; 277:31187-31200.

    DeLong CJ, Hicks AM, Cui Z. Disruption of choline methely group donation for phosphati-dylethanolamine methylation in hepatocarcinoma cells. J Biol Chem 2002; 277:17217-17225.

    DeLong CJ, Baker P, Samuel M, Cui Z, Thomas MJ. Molecular species composition of rat liver phospholipids by ESI-MS/MS: the effect of chromatography. J Lipid Res 2001; 42:1959-1968.


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