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Yao-Zhong Lin, Ph.D.

yaozhong_lin.jpg

YAO-ZHONG LIN, Ph.D.
President and CSO of Celtek Bioscience, LLC, Nashville, USA

Tel: 021-65983706-815 (China) and 615-399-7010 (USA)
Email: administrator@celtek-bioscience.com


EDUCATION

    1987-89   Postdoctoral Fellow, Biochemistry, Rockefeller University, NY, USA

    1987         Ph.D., Organic Chemistry, University of Massachusetts, Amherst, USA

    1976         B.S., Chemistry, Zhongshan University, China

 

POSITIONS HELD

    2002-present   President and CSO., Celtek Bioscience, LLC, Nashville, TN

    1991-2001        Assistant Professor, Department of Microbiology and Immunology

                     (91-99) and Dept. of Medicine (99-01), Vanderbilt University, Nashville, TN,

    1995-2001        Full Member, Vanderbilt University Cancer Center

    1989-1990        Research Associate, The Rockefeller University, New York, NY.

    1987-1989        Postdoctoral Fellow, The Rockefeller University, New York, NY.

    1982-1986        Research Assistant (graduate fellowship), Department of Chemistry,

                     University of Massachusetts at Amherst, MA.

    1981-1982        Teaching Assistant (graduate fellowship), Department of Chemistry,

                     University of Massachusetts at Amherst, MA.

 

PROFESSIONAL RECOGNITION

    Member of

    American Association for the Advancement of Science

    American Society for Microbiology American Chemical Society

    American Peptide Society

    Federation of American Societies for Experimental Biology

    International Society for Gene Therapy and Molecular Biology

    ad hoc grant reviewer of Biotechnology and Biological Sciences Research Council (bbsrc), United Kingdom, and Swiss Federal Institute of Technology Research Commission, and other USA agencies

    Reviewer of several biomedical and scientific journals

    Consultant of several USA biotechnology and biopharmaceutical companies

 

BIOGRAPHICAL SKETCH

    Dr. Lin earned his Ph.D. degree in organic chemistry at the University of Massachusetts at Amherst and had postdoctoral training in biochemistry at Rockefeller University. He was a member of the Vanderbilt faculty for ten years and a full member of the Vanderbilt Ingram Cancer Center. At Vanderbilt, his laboratory studied molecular mechanisms of signal transduction pathways associated with growth factors, oncogenes, cytokines, and transcription factors. Dr. Lin’s group also focused research efforts on development of new biotechnology methods, which can be useful for various cellular studies and drug discovery and development. His laboratory was the first one that invented and developed signal peptide and membrane-translocating sequence (MTS)-mediated peptide/protein delivery technology. Dr. Lin has demonstrated that this novel platform technology can be utilized to study various intracellular processes and to develop cell-permeable drug compounds. His research work has been published in a number of prestigious scientific journals including Nature Biotechnology and received high citations. His invention has also been the subject of eight (8) issued United States/international patents and a number of pending patent applications. Peptide/protein delivery study performed by Dr. Lin and his colleagues was supported by several grant awards from National Institute of Health (NIH) and American Cancer Society. His novel discovery and pioneer work were honored and featured in the 1998-1999 USA Congressional Budget Justification and reported as a Research Highlight by NIH/NIGMS and by several national and international newspapers and magazines including Nature Biotechnology. Dr. Lin has been a recognized expert and leader in the new field of peptide/protein intracellular delivery and has been an invited lecturer at major universities, research institutes, biotechnology & pharmaceutical companies, and scientific conferences. It is believed that his novel peptide cellular delivery work will significantly impact on R&D of new medicines for human cellular diseases, such as cancers.

 

SELECTED PUBLICATIONS

        Sadler K., Lin, Y. Z., and Tam, J.P. “Hydrophobic membrane translocating sequence (MTS) peptide” (2002), a book chapter in Cell Penetrating Peptide – Processes and Applications (CRC Press, Pharmacology & Toxicology series, edit. Ulo Langel), pp 115-140.

        Rojas, M., Donahue, J. P., Tan, Z., and Lin, Y. Z. “Genetic engineering of proteins with cell membrane permeability” (1998) Nature Biotechnology 16, 370-375.

        Du, C., Yao, S. Y., Rojas, M., and Lin, Y. Z. "Conformational and topological requirements of cell-permeable peptide function" (1998) Journal of Peptide Research 51, 235-243.

        Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y. Z., and Hawiger, J. "Regulation of NF-kB, AP-1, NF-AT, and STAT1 nuclear import in T lymphocytes by non-invasive delivery of peptide carrying the nuclear localization sequence of NF-kB p50" (1998) J. Immunology 161, 6084-6092.

        Rojas, M., Yao, S. Y., and Lin, Y. Z. "Controlling EGF-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor" (1996) J. Biol. Chem. 271, 27456-27461.

        Lin, Y. Z., Yao, S. Y., and Hawiger, J. "Role of the nuclear localization sequence in FGF-1-stimulated mitogenic pathways" (1996) J. Biol. Chem. 271, 5305-5308.

        Liu, X. -Y., Timmons, S., Lin, Y. Z., and Hawiger, J. "Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 using cell-permeable peptide analogs" (1996) Proc. Natl. Acad. Sci. USA. 93, 11819-11824.

        Lin, Y. Z., Yao, S. Y., Veach, R. A., Torgerson, T. R., and Hawiger, J. "Inhibition of nuclear translocation of transcription factor NF-kB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence" (1995) J. Biol. Chem. 270, 14255-14258.

        Lin, Y. Z., Ke, X. -H., and Tam, J. P. "Structure-activity study of myxoma virus growth factor" (1991) Biochemistry 30, 3310-3314.

        Lin, Y. Z., Ke, X. -H., and Tam, J. P. "Growth inhibition by vaccinia virus growth factor" (1990) J. Biol. Chem. 265, 18884-18890.

        Lin, Y. Z., Isacc, D. D., and Tam, J. P. "Synthesis and properties of chloecystokinin-releasing peptide (monitor peptide), a 61-residue trypsin inhibitor" (1990) Int. J. Peptide Protein Res. 36, 433-439.

        Carpino, L. A. and Lin, Y. Z. "Benz[f]indene" (1990) J. Org. Chem. 55, 247-250.

        Carpino, L. A., Cohen, B. J., Lin, Y. Z., Stephens, Jr., K. E. and Triolo, S. A. "The 2-chloro-3-indenylmethyloxycarbonyl and benz[f]-iden-3-ylmethyloxycarbonyl base-sensitive amino protecting groups. Application of an inverse Merrifield approach to the peptide synthesis " (1990) J. Org. Chem. 55, 251-258.

        Lin, Y. Z., Caporaso, G., Chang, P. -Y., Ke, X. -H. and Tam, J. P. "Synthesis of biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus" (1988) Biochemistry 27, 5640-5645.

 




Yao-Zhong Lin, Ph.D.

yaozhong_lin.jpg

YAO-ZHONG LIN, Ph.D.
President and CSO of Celtek Bioscience, LLC, Nashville, USA

Tel: 021-65983706-815 (China) and 615-399-7010 (USA)
Email: administrator@celtek-bioscience.com


EDUCATION

    1987-89   Postdoctoral Fellow, Biochemistry, Rockefeller University, NY, USA

    1987         Ph.D., Organic Chemistry, University of Massachusetts, Amherst, USA

    1976         B.S., Chemistry, Zhongshan University, China

 

POSITIONS HELD

    2002-present   President and CSO., Celtek Bioscience, LLC, Nashville, TN

    1991-2001        Assistant Professor, Department of Microbiology and Immunology

                     (91-99) and Dept. of Medicine (99-01), Vanderbilt University, Nashville, TN,

    1995-2001        Full Member, Vanderbilt University Cancer Center

    1989-1990        Research Associate, The Rockefeller University, New York, NY.

    1987-1989        Postdoctoral Fellow, The Rockefeller University, New York, NY.

    1982-1986        Research Assistant (graduate fellowship), Department of Chemistry,

                     University of Massachusetts at Amherst, MA.

    1981-1982        Teaching Assistant (graduate fellowship), Department of Chemistry,

                     University of Massachusetts at Amherst, MA.

 

PROFESSIONAL RECOGNITION

    Member of

    American Association for the Advancement of Science

    American Society for Microbiology American Chemical Society

    American Peptide Society

    Federation of American Societies for Experimental Biology

    International Society for Gene Therapy and Molecular Biology

    ad hoc grant reviewer of Biotechnology and Biological Sciences Research Council (bbsrc), United Kingdom, and Swiss Federal Institute of Technology Research Commission, and other USA agencies

    Reviewer of several biomedical and scientific journals

    Consultant of several USA biotechnology and biopharmaceutical companies

 

BIOGRAPHICAL SKETCH

    Dr. Lin earned his Ph.D. degree in organic chemistry at the University of Massachusetts at Amherst and had postdoctoral training in biochemistry at Rockefeller University. He was a member of the Vanderbilt faculty for ten years and a full member of the Vanderbilt Ingram Cancer Center. At Vanderbilt, his laboratory studied molecular mechanisms of signal transduction pathways associated with growth factors, oncogenes, cytokines, and transcription factors. Dr. Lin’s group also focused research efforts on development of new biotechnology methods, which can be useful for various cellular studies and drug discovery and development. His laboratory was the first one that invented and developed signal peptide and membrane-translocating sequence (MTS)-mediated peptide/protein delivery technology. Dr. Lin has demonstrated that this novel platform technology can be utilized to study various intracellular processes and to develop cell-permeable drug compounds. His research work has been published in a number of prestigious scientific journals including Nature Biotechnology and received high citations. His invention has also been the subject of eight (8) issued United States/international patents and a number of pending patent applications. Peptide/protein delivery study performed by Dr. Lin and his colleagues was supported by several grant awards from National Institute of Health (NIH) and American Cancer Society. His novel discovery and pioneer work were honored and featured in the 1998-1999 USA Congressional Budget Justification and reported as a Research Highlight by NIH/NIGMS and by several national and international newspapers and magazines including Nature Biotechnology. Dr. Lin has been a recognized expert and leader in the new field of peptide/protein intracellular delivery and has been an invited lecturer at major universities, research institutes, biotechnology & pharmaceutical companies, and scientific conferences. It is believed that his novel peptide cellular delivery work will significantly impact on R&D of new medicines for human cellular diseases, such as cancers.

 

SELECTED PUBLICATIONS

        Sadler K., Lin, Y. Z., and Tam, J.P. “Hydrophobic membrane translocating sequence (MTS) peptide” (2002), a book chapter in Cell Penetrating Peptide – Processes and Applications (CRC Press, Pharmacology & Toxicology series, edit. Ulo Langel), pp 115-140.

        Rojas, M., Donahue, J. P., Tan, Z., and Lin, Y. Z. “Genetic engineering of proteins with cell membrane permeability” (1998) Nature Biotechnology 16, 370-375.

        Du, C., Yao, S. Y., Rojas, M., and Lin, Y. Z. "Conformational and topological requirements of cell-permeable peptide function" (1998) Journal of Peptide Research 51, 235-243.

        Torgerson, T. R., Colosia, A. D., Donahue, J. P., Lin, Y. Z., and Hawiger, J. "Regulation of NF-kB, AP-1, NF-AT, and STAT1 nuclear import in T lymphocytes by non-invasive delivery of peptide carrying the nuclear localization sequence of NF-kB p50" (1998) J. Immunology 161, 6084-6092.

        Rojas, M., Yao, S. Y., and Lin, Y. Z. "Controlling EGF-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor" (1996) J. Biol. Chem. 271, 27456-27461.

        Lin, Y. Z., Yao, S. Y., and Hawiger, J. "Role of the nuclear localization sequence in FGF-1-stimulated mitogenic pathways" (1996) J. Biol. Chem. 271, 5305-5308.

        Liu, X. -Y., Timmons, S., Lin, Y. Z., and Hawiger, J. "Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 using cell-permeable peptide analogs" (1996) Proc. Natl. Acad. Sci. USA. 93, 11819-11824.

        Lin, Y. Z., Yao, S. Y., Veach, R. A., Torgerson, T. R., and Hawiger, J. "Inhibition of nuclear translocation of transcription factor NF-kB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence" (1995) J. Biol. Chem. 270, 14255-14258.

        Lin, Y. Z., Ke, X. -H., and Tam, J. P. "Structure-activity study of myxoma virus growth factor" (1991) Biochemistry 30, 3310-3314.

        Lin, Y. Z., Ke, X. -H., and Tam, J. P. "Growth inhibition by vaccinia virus growth factor" (1990) J. Biol. Chem. 265, 18884-18890.

        Lin, Y. Z., Isacc, D. D., and Tam, J. P. "Synthesis and properties of chloecystokinin-releasing peptide (monitor peptide), a 61-residue trypsin inhibitor" (1990) Int. J. Peptide Protein Res. 36, 433-439.

        Carpino, L. A. and Lin, Y. Z. "Benz[f]indene" (1990) J. Org. Chem. 55, 247-250.

        Carpino, L. A., Cohen, B. J., Lin, Y. Z., Stephens, Jr., K. E. and Triolo, S. A. "The 2-chloro-3-indenylmethyloxycarbonyl and benz[f]-iden-3-ylmethyloxycarbonyl base-sensitive amino protecting groups. Application of an inverse Merrifield approach to the peptide synthesis " (1990) J. Org. Chem. 55, 251-258.

        Lin, Y. Z., Caporaso, G., Chang, P. -Y., Ke, X. -H. and Tam, J. P. "Synthesis of biological active tumor growth factor from the predicted DNA sequence of Shope fibroma virus" (1988) Biochemistry 27, 5640-5645.

 




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