上海东方医院

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时东陆

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时东陆

教授,博导

国家千人计划(2012年)

现任,上海市东方医院纳米医学应用技术研究所,所长

同济大学医学院生物医学工程与纳米科学研究院,教授,院长

            同济大学转化医学高等研究院,PI, 教授

2001-  美国辛辛那提大学,材料科学与工程系,终身正教授

2001/03—2002/03, 英国剑桥大学Fitzwilliam College Fellow;法国国家科学中心研究员 

1995/01—2011/09, 美国辛辛那提大学,材料科学与工程系,副教授

1988/07—1995/01, 美国阿贡国家实验室正式研究员, PI

1986/09—1988/07, 美国阿贡国家实验室博士后

 

国际杂志主编与评委

NANO-LIFE 主编

Materials Science & Engineering: C 副主编

Journal of Nanomaterials 副主编

Particle and Particle Systems Characterization 编委

Tsinghua Science and Technology 编委

《生物物理》杂志编委

Nature, Advanced Materials, ACS NANO, Angewandte Chemie 评审

美国 NanoTech Review Committee Member

美国达特茅斯学院肿瘤研究中心评委

美国NSF评委, 中国NSFC评委     

 

学术界奖项

2012年入选中组部 国家千人计划 (国家千人)。

2014, 2015, 2016 Elsevier 中国学者高被引用率榜;

2010年入选国务院外国专家局 “海外高层次文教专家重点支持计划” (海外大师)

2012年同济大学优秀博士后合作导师

2011年同济大学优秀博士后合作导师

2012年美国Composites Part B: Engineering, "The Top 10 Most Cited Papers"

University of Cincinnati Graduate Fellow

Distinguished Engineering Researcher

Sigma XI Outstanding Research Award

Neil Wandwacher Outstanding Teaching Award

The BFGOODRICH Collegiate Invention Award

Member of National Academy of Inventors

 

学术论文

已经发表SCI论文270多篇 (2017年)。H因子46 。2005年首创多功能纳米智能载体新概念。在纳米影像学,纳米送药,细胞靶向等领域做出重要贡献。先后在Nature, Physical Review Letters, Advanced Materials,ACS NANO 等国际一流学术期刊上发表开创性论文。受邀在世界著名杂志Advanced Functional MaterialsSmall撰写纳米医学肿瘤诊疗综述文章。12部材料学与纳米医学专著。

 

代表性论著

1.   Shuyang Sun, Yilong Wang, Rong Zhou, Zicheng Deng, Yong Han, Xiao Han,   

Wenjie Tao, Zi Yang, Chaoji Shi, Duo Hong, Jiang Li, Donglu Shi, and Z. Zhang

“Targeting and Regulating of an Oncogene via Nanovector Delivery of MicroRNA using Patient-Derived Tumor Xenografts,”

Theranostics (2017) 7, 3, 677 (IF=8.854)

2.     Xiao Han, Zicheng Deng, Zi Yang, Yilong Wang, Huanhuan Zhu, Bingdi Chen,  

Zheng Cui, Rodney C. Ewing and Donglu Shi, “Biomarkerless targeting and photothermal cancer cell killing by surface-electrically-charged superparamagnetic Fe3O4 composite nanoparticles,”

Nanoscale, (2017), 9, 1457-1465 (IF=7.394)

3.     Bingmei Sun, Jinrui Wu, Shaobin Cui, Huanhuan Zhu, Wei An, Qingge Fu,  

Chengwei Shao, Aihua Yao, Bingdi Chen, and Donglu Shi, “In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy,”

Nano Research (2017), 10, 1, 37–48 (IF=8.893)         

4.     Bingbo Zhang, Weitao Yang, Jiani Yu, Weisheng Guo, Jun Wang, Shiyuan Liu,  

Yi Xiao, and Donglu Shi, “Green Synthesis of Sub-10 nm Gadolinium-Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor-Bearing Mice in Magnetic Resonance Imaging,”

Adv. Healthcare Mater. (2017), 6. 1600865 (IF=5.76)

5.       Bingdi Chen,Wenjun Le,Yilong Wang, Zhuoquan Li, Dong Wang, Lei Ren,  Ling Lin, Shaobin Cui,Jennifer J. Hu, Yihui Hu, Pengyuan Yang, Rodney C. Ewing, Donglu Shi, Zheng Cui, "Targeting Negative Surface Charges of   Cancer Cells by Multifunctional Nanoprobe,” 

Theranostics, (2016); 6(11): 1887–1898.   (IF=8.854)    

6.       Fangjie Wo, Rujiao Xu, Yuxiang Shao, Zheyu Zhang, Maoquan Chu, Donglu Shi, Shupeng Liu, "A Multimodal System with Synergistic Effects of Magneto- Mechanical, Photothermal, Photodynamic and Chemo Therapies of Cancer in Graphene-Quantum Dot-Coated Hollow Magnetic Nanospheres," 

Theranostics, (2016), Vol. 6, Issue 4 (IF=8.854)

7.       Xiaohong Xing, Bingbo Zhang, Xiaohui Wang, Fengjun Liu, Donglu Shi, Yingsheng Cheng, “An “imaging-biopsy” strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots,” 

Biomaterials 48 (2015) 16e25 (IF=8.387)

8.       Donglu Shi, M. E. Sadat, Andrew W. Dunn, David B. Mast, "Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications," 

Nanoscale, 7, 8209-8232(2015) (IF=7.394)

9.       Xiaowei Li, Xiaoyan Liu, Donglu Shi, Xuejun Wen, "Particle Systems for Stem Cell Applications, "

Journal of biomedical nanotechnology, 11, 1107-1123 (2015)

Invited Review Article (IF=5.338)

10.       Feng Wang, G. M. Pauletti, Juntao Wang, J. M. Zhang, R. C. Ewing, Y L Wang, Donglu Shi, "Dual Surface-functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2 for Simultaneous Tumor Cell Targeting and Stimulus-induced Drug Release,"

Advanced Materials Vol.25, No.25, 3485-3489, (2013) (IF=17.493)

11.    Haiqing Dong, Yongyong Li, Jinhai Yu, Yanyan Song, Xiaojun Cai, Jiaqiang Liu, Jiaming Zhang, Rodney C. Ewing, and Donglu Shi, "A Versatile Multicomponent Assembly via β -cyclodextrin Host–Guest Chemistry on Graphene for Biomedical Applications,"

Small, DOI:10.1002/smll.201201003 (2012) (IF=8.368)

12.    H. Y. Wen with Donglu Shi, “Engineered Redox-Responsive PEG Detachable Mechanism in PEGylated Nano-graphene Oxide for Intracellular Drug Delivery,” 

Small, 8, 5, 760-769 (2012) (IF=8.368)

13.    Yan Guo, Donglu Shi, Wei Wang, Jie Lian, G. K. Liu, Z. Y. Dong, L. M. Wang, and Rodney C. Ewing, “In vivo Imaging by Luminescent Nanotubes”, 19, 4033–4037, 

Advanced Materials (2007) (IF=17.493)

14.    Donglu Shi, Hoon Sung Cho, Chris Huth, Wei Wang, Jie Lian, G. K. Liu, L. M. Wang, Rodney C. Ewing, Giovanni Pauletti, Z. Y. Dong, “Fluorescent Polystyrene–Fe3O4 Composite Nanospheres for in vivo Imaging and Hyperthermia,”21, 1-4, 

Advanced Materials (2009) (IF=17.493)

15.    Donglu Shi, “Integrated Multi-Functional Nano Systems for Medical Diagnosis and Treatment,”

Advanced Functional Materials, 21, (2009), Invited Review Article. (IF=11.805)

16.    Donglu Shi, Jie Lian, H. Peng, Wei Wang, Zhongyun Dong, L. M. Wang, and Rodney C. Ewing, “In vivo Imaging by Luminescent Carbon Nanotubes with Surface Conjugated Quantum Dots,”

Advanced Functional Materials, 18, 1-9 (2008) (IF=11.805)

17.    H. Cho, Z. Dong, G. M. Pauletti, J. Zhang, Hong Xu, H. Gu, Lumin Wang, Rodney C. Ewing, Christopher Huth, Feng Wang, and Donglu Shi, "Fluorescent, Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging," 

ACS NANO, 4 (9), pp 5398–5404 (2010)

18.    Ling Yang, Michael K. Miller, Xun-Li Wang, Chain T. Liu, Alexandru, D. Stoica, Dong Ma, Jonathan Almer, and Donglu Shi, “Nanoscale Solute Partitioning in Bulk Metallic Glasses,” 

Advanced Materials 20, 1–4 (2008) (IF=17.493)

19.    Donglu Shi, Wei Wang, Jie Lian, G. K. Liu, Z. Y. Dong, L. M. Wang, and Rodney C. Ewing, “Luminescent Carbon Nanotubes”, 18, 189-193, 

Advanced Materials (2006) (IF=17.493)

20.    Donglu Shi, Hoon Song Cho, Nick Bedford, "Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics,"Invited Review Article, 

Small,7, 18, 2549–2567, (2011) (IF=8.368)

21.    D. G. Hinks, B. Dabrowski, J. D. Jorgensen, A. W. Mitchell, D. R. Richards, Shiyou Pei, and Donglu Shi, Synthesis, Structure, and Superconductivity in the Ba1-xKxBiO3-y System,

Nature 333, 836-838 (1988) (IF=41.456)

22.   Zhengquan Tan, M. E. Filipkowski, J. I. Budnick, E. K. Heller, D. L. Brewe, B. L. Chamberland, C. E. Bouldin, J. C. Woicik, and Donglu Shi, Strontium-Induced Oxygen Defect Structure and Hole Doping in La2-xSrxCu O4, 

Phys. Rev. Lett. 64, 2715-2718 (1991) (IF=7.645) 

 

学术专著:

1. Biomaterials and Tissue Engineering (Springer-Verlag, 2004)

2. Medical Devices and Their Applications (Springer-Verlag, 2004)

3. Nanostructured Magnetic Materials and Their Applications (Springer-Verlag, 2002)

4. Functional Thin Films-New Concepts and Technologies (Springer and TUP, 2002)

5. High Temperature Superconducting Materials Sci. and Eng. (Pergamon Press, 1994)    

6. Introduction to Biomaterials (Tsinghua University Press and World Scientific, 2006)

7. NanoScience in Biomedicine (Springer and Tsinghua University Press, 2008)

8. Nanomaterials and Devices (Elsevier and Tsinghua University Press, 2014)

9. Bio-Inspired Nano Materials (World Scientific 2014)

10. The World Scientific Encyclopedia of Nanomedicine and Bioengineering I (World Scientific 2016) http://www.worldscientific.com/worldscibooks/10.1142/9560

11. The World Scientific Encyclopedia of Nanomedicine and Bioengineering II (World Scientific 2017)

12. Tissue Engineering and Nano Theranostics (World Scientific, 2017)


时东陆

时东陆.jpg

时东陆

教授,博导

国家千人计划(2012年)

现任,上海市东方医院纳米医学应用技术研究所,所长

同济大学医学院生物医学工程与纳米科学研究院,教授,院长

            同济大学转化医学高等研究院,PI, 教授

2001-  美国辛辛那提大学,材料科学与工程系,终身正教授

2001/03—2002/03, 英国剑桥大学Fitzwilliam College Fellow;法国国家科学中心研究员 

1995/01—2011/09, 美国辛辛那提大学,材料科学与工程系,副教授

1988/07—1995/01, 美国阿贡国家实验室正式研究员, PI

1986/09—1988/07, 美国阿贡国家实验室博士后

 

国际杂志主编与评委

NANO-LIFE 主编

Materials Science & Engineering: C 副主编

Journal of Nanomaterials 副主编

Particle and Particle Systems Characterization 编委

Tsinghua Science and Technology 编委

《生物物理》杂志编委

Nature, Advanced Materials, ACS NANO, Angewandte Chemie 评审

美国 NanoTech Review Committee Member

美国达特茅斯学院肿瘤研究中心评委

美国NSF评委, 中国NSFC评委     

 

学术界奖项

2012年入选中组部 国家千人计划 (国家千人)。

2014, 2015, 2016 Elsevier 中国学者高被引用率榜;

2010年入选国务院外国专家局 “海外高层次文教专家重点支持计划” (海外大师)

2012年同济大学优秀博士后合作导师

2011年同济大学优秀博士后合作导师

2012年美国Composites Part B: Engineering, "The Top 10 Most Cited Papers"

University of Cincinnati Graduate Fellow

Distinguished Engineering Researcher

Sigma XI Outstanding Research Award

Neil Wandwacher Outstanding Teaching Award

The BFGOODRICH Collegiate Invention Award

Member of National Academy of Inventors

 

学术论文

已经发表SCI论文270多篇 (2017年)。H因子46 。2005年首创多功能纳米智能载体新概念。在纳米影像学,纳米送药,细胞靶向等领域做出重要贡献。先后在Nature, Physical Review Letters, Advanced Materials,ACS NANO 等国际一流学术期刊上发表开创性论文。受邀在世界著名杂志Advanced Functional MaterialsSmall撰写纳米医学肿瘤诊疗综述文章。12部材料学与纳米医学专著。

 

代表性论著

1.   Shuyang Sun, Yilong Wang, Rong Zhou, Zicheng Deng, Yong Han, Xiao Han,   

Wenjie Tao, Zi Yang, Chaoji Shi, Duo Hong, Jiang Li, Donglu Shi, and Z. Zhang

“Targeting and Regulating of an Oncogene via Nanovector Delivery of MicroRNA using Patient-Derived Tumor Xenografts,”

Theranostics (2017) 7, 3, 677 (IF=8.854)

2.     Xiao Han, Zicheng Deng, Zi Yang, Yilong Wang, Huanhuan Zhu, Bingdi Chen,  

Zheng Cui, Rodney C. Ewing and Donglu Shi, “Biomarkerless targeting and photothermal cancer cell killing by surface-electrically-charged superparamagnetic Fe3O4 composite nanoparticles,”

Nanoscale, (2017), 9, 1457-1465 (IF=7.394)

3.     Bingmei Sun, Jinrui Wu, Shaobin Cui, Huanhuan Zhu, Wei An, Qingge Fu,  

Chengwei Shao, Aihua Yao, Bingdi Chen, and Donglu Shi, “In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy,”

Nano Research (2017), 10, 1, 37–48 (IF=8.893)         

4.     Bingbo Zhang, Weitao Yang, Jiani Yu, Weisheng Guo, Jun Wang, Shiyuan Liu,  

Yi Xiao, and Donglu Shi, “Green Synthesis of Sub-10 nm Gadolinium-Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor-Bearing Mice in Magnetic Resonance Imaging,”

Adv. Healthcare Mater. (2017), 6. 1600865 (IF=5.76)

5.       Bingdi Chen,Wenjun Le,Yilong Wang, Zhuoquan Li, Dong Wang, Lei Ren,  Ling Lin, Shaobin Cui,Jennifer J. Hu, Yihui Hu, Pengyuan Yang, Rodney C. Ewing, Donglu Shi, Zheng Cui, "Targeting Negative Surface Charges of   Cancer Cells by Multifunctional Nanoprobe,” 

Theranostics, (2016); 6(11): 1887–1898.   (IF=8.854)    

6.       Fangjie Wo, Rujiao Xu, Yuxiang Shao, Zheyu Zhang, Maoquan Chu, Donglu Shi, Shupeng Liu, "A Multimodal System with Synergistic Effects of Magneto- Mechanical, Photothermal, Photodynamic and Chemo Therapies of Cancer in Graphene-Quantum Dot-Coated Hollow Magnetic Nanospheres," 

Theranostics, (2016), Vol. 6, Issue 4 (IF=8.854)

7.       Xiaohong Xing, Bingbo Zhang, Xiaohui Wang, Fengjun Liu, Donglu Shi, Yingsheng Cheng, “An “imaging-biopsy” strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots,” 

Biomaterials 48 (2015) 16e25 (IF=8.387)

8.       Donglu Shi, M. E. Sadat, Andrew W. Dunn, David B. Mast, "Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications," 

Nanoscale, 7, 8209-8232(2015) (IF=7.394)

9.       Xiaowei Li, Xiaoyan Liu, Donglu Shi, Xuejun Wen, "Particle Systems for Stem Cell Applications, "

Journal of biomedical nanotechnology, 11, 1107-1123 (2015)

Invited Review Article (IF=5.338)

10.       Feng Wang, G. M. Pauletti, Juntao Wang, J. M. Zhang, R. C. Ewing, Y L Wang, Donglu Shi, "Dual Surface-functionalized Janus Nanocomposites of Polystyrene/Fe3O4@SiO2 for Simultaneous Tumor Cell Targeting and Stimulus-induced Drug Release,"

Advanced Materials Vol.25, No.25, 3485-3489, (2013) (IF=17.493)

11.    Haiqing Dong, Yongyong Li, Jinhai Yu, Yanyan Song, Xiaojun Cai, Jiaqiang Liu, Jiaming Zhang, Rodney C. Ewing, and Donglu Shi, "A Versatile Multicomponent Assembly via β -cyclodextrin Host–Guest Chemistry on Graphene for Biomedical Applications,"

Small, DOI:10.1002/smll.201201003 (2012) (IF=8.368)

12.    H. Y. Wen with Donglu Shi, “Engineered Redox-Responsive PEG Detachable Mechanism in PEGylated Nano-graphene Oxide for Intracellular Drug Delivery,” 

Small, 8, 5, 760-769 (2012) (IF=8.368)

13.    Yan Guo, Donglu Shi, Wei Wang, Jie Lian, G. K. Liu, Z. Y. Dong, L. M. Wang, and Rodney C. Ewing, “In vivo Imaging by Luminescent Nanotubes”, 19, 4033–4037, 

Advanced Materials (2007) (IF=17.493)

14.    Donglu Shi, Hoon Sung Cho, Chris Huth, Wei Wang, Jie Lian, G. K. Liu, L. M. Wang, Rodney C. Ewing, Giovanni Pauletti, Z. Y. Dong, “Fluorescent Polystyrene–Fe3O4 Composite Nanospheres for in vivo Imaging and Hyperthermia,”21, 1-4, 

Advanced Materials (2009) (IF=17.493)

15.    Donglu Shi, “Integrated Multi-Functional Nano Systems for Medical Diagnosis and Treatment,”

Advanced Functional Materials, 21, (2009), Invited Review Article. (IF=11.805)

16.    Donglu Shi, Jie Lian, H. Peng, Wei Wang, Zhongyun Dong, L. M. Wang, and Rodney C. Ewing, “In vivo Imaging by Luminescent Carbon Nanotubes with Surface Conjugated Quantum Dots,”

Advanced Functional Materials, 18, 1-9 (2008) (IF=11.805)

17.    H. Cho, Z. Dong, G. M. Pauletti, J. Zhang, Hong Xu, H. Gu, Lumin Wang, Rodney C. Ewing, Christopher Huth, Feng Wang, and Donglu Shi, "Fluorescent, Superparamagnetic Nanospheres for Drug Storage, Targeting, and Imaging," 

ACS NANO, 4 (9), pp 5398–5404 (2010)

18.    Ling Yang, Michael K. Miller, Xun-Li Wang, Chain T. Liu, Alexandru, D. Stoica, Dong Ma, Jonathan Almer, and Donglu Shi, “Nanoscale Solute Partitioning in Bulk Metallic Glasses,” 

Advanced Materials 20, 1–4 (2008) (IF=17.493)

19.    Donglu Shi, Wei Wang, Jie Lian, G. K. Liu, Z. Y. Dong, L. M. Wang, and Rodney C. Ewing, “Luminescent Carbon Nanotubes”, 18, 189-193, 

Advanced Materials (2006) (IF=17.493)

20.    Donglu Shi, Hoon Song Cho, Nick Bedford, "Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics,"Invited Review Article, 

Small,7, 18, 2549–2567, (2011) (IF=8.368)

21.    D. G. Hinks, B. Dabrowski, J. D. Jorgensen, A. W. Mitchell, D. R. Richards, Shiyou Pei, and Donglu Shi, Synthesis, Structure, and Superconductivity in the Ba1-xKxBiO3-y System,

Nature 333, 836-838 (1988) (IF=41.456)

22.   Zhengquan Tan, M. E. Filipkowski, J. I. Budnick, E. K. Heller, D. L. Brewe, B. L. Chamberland, C. E. Bouldin, J. C. Woicik, and Donglu Shi, Strontium-Induced Oxygen Defect Structure and Hole Doping in La2-xSrxCu O4, 

Phys. Rev. Lett. 64, 2715-2718 (1991) (IF=7.645) 

 

学术专著:

1. Biomaterials and Tissue Engineering (Springer-Verlag, 2004)

2. Medical Devices and Their Applications (Springer-Verlag, 2004)

3. Nanostructured Magnetic Materials and Their Applications (Springer-Verlag, 2002)

4. Functional Thin Films-New Concepts and Technologies (Springer and TUP, 2002)

5. High Temperature Superconducting Materials Sci. and Eng. (Pergamon Press, 1994)    

6. Introduction to Biomaterials (Tsinghua University Press and World Scientific, 2006)

7. NanoScience in Biomedicine (Springer and Tsinghua University Press, 2008)

8. Nanomaterials and Devices (Elsevier and Tsinghua University Press, 2014)

9. Bio-Inspired Nano Materials (World Scientific 2014)

10. The World Scientific Encyclopedia of Nanomedicine and Bioengineering I (World Scientific 2016) http://www.worldscientific.com/worldscibooks/10.1142/9560

11. The World Scientific Encyclopedia of Nanomedicine and Bioengineering II (World Scientific 2017)

12. Tissue Engineering and Nano Theranostics (World Scientific, 2017)


上海市东方医院 纳米医学应用技术研究所

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