擅长脑血管病、帕金森病和其他神经系统疑难疾病的诊疗
教授
科主任
教授
毕业于华中科技大学同济医学院医疗系，获德国Ulm大学神经病学博士学位，曾在德国Freiburg大学和美国 Baylor医学院学习工作多年。主要从事脑血管病和神经退行性疾病的诊疗，在脑梗死急性期溶栓治疗、脑梗死病因学诊断和针对性防治、帕金森病早期诊断及个体化全程管理具有丰富经验。 任上海市医学会神经内科专业委员会帕金森学组成员、上海中西医结合学会慢性神经系统疾病专业委员会副主任委员、 中国医师协会中西医结合学会神经病学分会委员、中国卒中学会脑卒中康复委员会委员、中国卒中学会脑血管病高危人群管理委员会委员等。《同济大学学报（医学版）》和《卒中（中文版）》编委。主持包括国家自然基金等国家级、上海市科委等多项科研课题。 获国家发明专利5项。在国内外核心专业杂志发表学术论文80余篇，SCI论文30篇，包括《FASEB》、《PNAS》、《Brain Stimul》等杂志，主编主译专著5部。
教授
DAAD最佳留学生
1. Yanyan Jiang,Hedi An,Qian Xi,Weiting Yang, Hongrong Xie, Yang Li and
Dongya Huang. Diffusion Tensor Imaging Reveals Deep Brain Structure Changes in Early Parkinson’s Disease Patients with Various Sleep Disorders.Brain Sci.2022,12,463.
2. Lufeng Wang,Hedi An,Fei Yu,Jie Yang,Hao Ding, Hongrong Xie, Dongya
Huang. The neuroprotective effects of paeoniflorin against MPP+-induced damage to dapaminergic neurons via the Akt/Nrf2/GPX4 pathway. Journal of Chemical Neuroanatomy, 2022,122,102103.
3. Yiwen Bao,Fei Yu,Liang Wei, Wenxia Zhu,Lufeng Wang, Hao Ding, Jie Yang, Dongya Huang. Association between Cognitive Decline and Altered Cerebral Perfusion in Adults with Moyamoya Disease after Revascularization. Cerebrovascular Diseases. 2022.April 27.DOI:10.1159/000524240.
4. Lei Shen, Kaige Zhou, Hongliu, Jie Yang,Shuqi Huang, Fei Yu and Dongya
Huang: Prediction of Mechanosensitive Genes in Vascular Endothelial Cells Under High Wall Shear Stress. Frontiers in Genetics, 2022 Jan.12:Article 796812.
5. Yu Zhang, Zi en Zhang, De Shi, Yi Zhao, Lihong Huang, Yanxin Zhao, Hui
Wang, Jing Zhao, Feng Wang, Chaorong Zhao, Shan Gao, Wenshi Wei, Dongya Huang* and Zhenguo Liu: Nocturnal Sleep Problems Mediate the Impact on Quality of Life of Early Morning Off in Parkinson’s Disease. Frontiers in aging neuroscience ( Front. Aging Neurosci.), 2021, aug, 06,13:681773. doi:10.3389/fnagi.2021.681773
6. Xiaoyan Zeng, Hedi An, Feiyu, Kai Wang, Lanlan Zheng, Wei Zhou, Yiwen Bao,
Jeiyang, Nan Shen, Dongya Huang*: Benefits of iron chelators in the treatment of parkinson’s disease. Neurochem Res. 2021 May,46(5):1239-1251
7. Yingying Lin, Shijie Guo,Xueyuan Liu，Dongya Huang*: Metabolic syndrome is
associated with cognitive impairment after transient ischemic attack/mild stroke, but does not affect cognitive recovery in short term. NeuroReport, 2020, 31: 918-922
8. Yu Zhang, Jia hao Zhao, Dong ya Huang, Wei Chen, Can xing Yuan, Li rong
Jin, Yu hui Wang , Ling jing Jin, Lei lu, Xiao ping Wang, Chang de Wang, Xiao hui Zhao, Xi Zhang, Wen tao Li and Zhen guo Liu: Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients. npj/Parkinson’s Disease, 2020, Sep 15, 6(25): doi: 10.1038/s41531-020-00126-x. e Collection 2020.
9. Ying-Ying Lin，Shi-Jie Guo，Hui Quan，Yan-Xin Zhao and Dong-Ya Huang*：
Donepezil Improves Gait Performance in Patients with an acute cerebral infarction: A Prospective Observational Cohort Study. Current Neurovascular Research, 2020,17(3):1-8.
10. Ying-Ying Lin,Tong-ya Yu,Hui Quan,Yu-Juan Chen,Xue-Yuan Liu, Dong-Ya
Huang*: Association between PSD95 Gene 3'UTR Single Nucleotide Polymorphism and Risk of Acute Ischemic Stroke in Chinese Han Population. (Jounal of Molecular Neuroscience), J Mol Neurosci,2020,5.14.
11. Liu H, Yang J, Wang K, Niu T, Huang D*: Moderate-and low-Dose of
Atorvastatin alleviate cognition impairment induced by High-fat diet via Sirt1 activationl. Neurochem Res. , 2019, 44(5):1065-1078.
12. Huang C, Chu H, Ma Y, Zhou Z, Dai C, Huang X, Fang L, Ao Q, Huang D*.:
Theneuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease. Brain Stimul. 2019 Jan - Feb; 12(1): 161-174.
13. Hedi An ,1, Xiaoyan Zeng ,1, Tengfei Niu , Gaiying Li , Jie Yang , Lanlan
Zheng , Wei Zhou, Hong Liu, Miaomiao Zhang, Dongya Huang*, Jianqi Li：Quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping. Journal of the Neurological Sciences，2018， 386：46-52.
14. Zhao X，An H，Liu T，Shen N, Bo B, Zhang Z, PF Weng, M Chen, M Pei, Y.
Wang, Dongya Huang* , Jianqi Li：Quantitative Susceptibility Mapping of the Substantia Nigra in Parkinson’s Disease，Applied Magnetic Resonance，2017, 48(6): 533—544.
15. Jie Yang, Fei Yu, Hong Liu, Hedi An, Ran Xiong, Dongya Huang：A Retro-
spective Study of thrombolysis with 0.6mg/kg Recombinant Tissue Plasminogen Activator (rt-PA) in Mild Stroke. Scientific Reports, 2016，6:31344.
16. Zhilan Tu, Bo Yu, Dongya Huang *, Rajeev Ojha, Shu-Kui Zhou, He-Di An,
Rong Liu, Cui Du, Nan Shen, Jian-Hui Fu, Shuang-Xing Hou : Proteomic analysis and comparison of intra- and extra- cranial cerebral atherosclerosis response to hyperlipidemia in rabbits. Molecular Medicine Reports, 2017, 16:2347-2354.
17. Zhilan Tu, Dongya Huang, Hedi An, Ojha Rajeev, Fei Yu, Rong Liu, Cui Du:
Effect of dyslipidemia on imt of intra- and extracranial atherosclerosis by regulating the expression of hsp70 in rabbits, Int J Clin Exp Med. 2015 Apr 15; 8(4):5446-53.
18. Hedi An, Ojha Rajeev, Dongya Huang*, Jiajun Yang, Jianqi Li, Fei Yu, Rong Liu,
Cui Du, Yue Zhang, Wenxia Zhu：Influence of internal carotid artery stenosis, blood pressure, glycated hemoglobin, and hemoglobin level on fMRI signals of stroke patients，Neurol Res. 2015，37（6）：502-509.
19. Ojha R, Huang D, An H, Liu R, Du C, Shen N, Tu Z, Li Y.：Distribution of
ischemic infarction and stenosis of intra- and extracranial arteries in young Chinese patients with ischemic stroke. BMC Cardiovasc Disord. 2015 Nov 23;15(1):158.
20. D.Y. Huang, A. Shenoy, J.K. Cui, W.Y. Huang and P.K. Liu: In situ
detection of AP sites and DNA strand breaks bearing 3´ phosphate termini in ischemic mouse brain. FASEB, 14, 2000: 407-417.
21. E.F. Greiner, J.Kirfel, H. Greschik, D.Y.Huang and R. Schuele: Differential
ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor. PNAS, 97, 2000: 7160-7165.
22. P.K. Liu, Jiankun Cui, Niki Moore, D.Y. Huang,: In Situ Detection of DNA
Damage: Methods and Protocols ( Methods in Molecular Biology, Vol 203), 2002.
1. Alzheimer 症临床诊断试剂研制，上海市科委重点项目(034319213)
2. 缺血性脑血管病的病因学研究及其防治, 同济大学人才建设项目(1500144001)
3. 短暂性脑缺血发作与颈动脉粥样硬化病变的，院级项目(DF2005R02)
4. 浦东地区青年脑梗死与GPIaC807T基因SNPs的相关性研究，浦东新区科委项目(PKJ2009-Y17)
5. BOLD-fMRI对脑梗塞后运动功能重塑的评估，上海市磁共振重点实验室开放课题
6. 封装CX3CL1转染的间充质干细胞对ALS的神经保护作用, 上海市科委重点基础项目（13JC1407103）
7. 脑血管病整体康复适宜技术的开发推广及康复信息平台的建设，十二五国家科技支撑计划（2011BAI08B11）
8. MRI-QSM检测帕金森病黑质铁沉积的临床研究，上海市科委（201540392）
9. TRPM2/CREB通路在缺血/再灌注导致神经元损伤中的作用，国家自然科学基金（81771258）
10. 创新型五禽戏改善帕金森病中轴症状的随机、多中心、前瞻性、对照临床研究国家重点研发计划（2017YFC1310304）
11. 人源神经干细胞（ANGE-S004）治疗阿尔茨海默病单中心、随机、双盲、安慰剂平行对照临床研究，国家备案项目（ChiCTR1900028744）
DAAD最佳留学生
1. 脑缺血后神经细胞的氧化 DNA损伤与修复和再生机制的研究
2. 帕金森病的临床和基础研究
3. 干细胞治疗AD/PD的临床和基础研究
