医学博士、教授、博士生导师。毕业于华中科技大学同济医学院，英国剑桥大学访问学者。从事妇产科临床、教学和研究工作20余年，积累了丰富的临床经验。 临床主攻：子宫颈癌前病变、宫颈癌、妇科良、恶性肿瘤的诊断、手术、和综合治疗。 主持国家自然基金、科技部重大项目、上海市科委、上海市申康等研究课题20余项。以第一或通讯作者在NAR,JECCR等SCI收录期刊上发表论著30余篇。授权发明专利2项，实用新型专利5项。获上海市医学科技奖1项。主编论著1部。 发表文章： 1. Yang, M.#, Hu, H.#, Wu, S., Ding, J., Yin, B., Huang, B., Li, F.*, Guo, X.*, & Han, L*. (2022). EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression. Journal of experimental & clinical cancer research : CR, 41(1), 165. 2. Yin Bo#, Ding Jianyi#, Hu Haoran#, Yang Meiqin, Huang Baoyou, Dong Wei*, Li Fang*, Han Lingfei*. Overexpressed CMTM6 improves prognosis and associated with immune infiltrates of ovarian cancer. Front Mol Biosci.2021. 3. Le Fu#, Wei Xia#, Wei Shi, Guangxu Cao, Yetian Ruana, Xingyu Zhao, Min Liu, Sumei Niu, Fang Li*, Xin Gao*. Deep learning based cervical screening by the cross-modal integration of colposcopy, cytology, and HPV test. International Journal of Medical Informatics,159 (2022) 104675. 4. Xinxin Xu#, Zhiqiang Han#, Yetian Ruan, Min Liu, Guangxu Cao, Chao Li*, Fang Li*. HPV16-LINC00393 integration alters local 3D genome architecture in cervical cancer cells. Front Cell Infect Microbiol. 2021 Dec 7;11:785169. 5. Zhiyuan Huang#, Fang Li*, Qinchuan Li*. Expression profile of RNA binding protein in cervical cancer using bioinformatics approach. Cancer Cell Int. 2021 Dec 4;21(1):647. 6. Li Y#, Gong YX#, Wang Q, Gao S, Zhang H, Xie F, Cong Q, Chen L, Zhou Q, Hong Z, Qiu L, Li F, Xie Y*, Sui L*. Optimizing the Detection of Occult Cervical Cancer: A Prospective Multicentre Study in China. Int J Womens Health. 2021 Oct 27;13:1005-1015. 7. Zhu J#, Chen F, Luo L, Wu W, Dai J, Zhong J, Lin X, Chai C, Ding P, Liang L, Wang S, Ding X, Chen Y, Wang H, Qiu J, Wang F, Sun C, Zeng Y, Fang J, Jiang X, Liu P, Tang G, Qiu X, Zhang X, Ruan Y, Jiang S, Li J, Zhu S, Xu X, Li F, Liu Z, Cao G*, Chen D*. Single-cell atlas of domestic pig cerebral cortex and hypothalamus. Science Bulletin 2021, 66(14): 1448-1461. 8. Ruan Y#, Liu M, Guo J, Zhao J, Niu S, Li Fang*, Evaluation of the accuracy of colposcopy in detecting high-grade squamous intraepithelial lesion and cervical cancer. Arch Gynecol Obstet. 2020 Aug;10.1007/s00404-020-05740-x. 9. Guo, Junhan#, Fu Le#, Zhao Junwei, Lei Lei, Zhan Qin, Liu Min, Ruan Yetian, Li Hui, Xu Jin, Li Nana, Wang Hanlin, Zhu Huiting, Han Zhiqiang, Li Fang*, The value of microendoscopy in the diagnosis of cervical precancerous lesions and cervical microinvasive carcinoma. Archives of Gynecology and Obstetrics. 2020 June 302. 10. Wen Yu#, Cai Long, Tailin Zhu, Huiting Zhu, Zhiqiang Han*, Fang Li*, High resolution multispectral endoscopy significantly improves the diagnostic accuracy of cervical intraepithelial lesions. Journal of obstetrics and gynaecology research, 2020 April, 46: 939-944. 11. Chao Li#*, Hongfeng Ao#, Guofang Chen, Fang Wang, Fang Li*. The Interaction of CDH20 With β-Catenin Inhibits Cervical Cancer Cell Migration and Invasion via TGF-β/Smad/SNAIL Mediated EMT. Front Oncol. 2020 Jan 9;9:1481. 12. Junwei Zhao#, Qin Zhan, Junhan Guo, Min Liu, Yetian Ruan, Tailin Zhu, Lingfei Han*, Fang Li*. Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai. Infect Agent Cancer. 2019 Nov 21;14:38. 13. Junwei Zhao#, Jiacheng Zhu, Junhan Guo, Tailin Zhu, Jixing Zhong, Min Liu, Yetian Ruan, Shujie Liao*, Fang Li*. Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women. J Med Virol. 2020 Mar;92(3):372-381. 14. Chao Li#*, Yanfei Li#, Lanxia Sui, Jian Wang, Fang Li*, Phenyllactic acid promotes cell migration and invasion in cervical cancer via IKK/NF-κB-mediated MMP-9 activation. Cancer Cell Int. 2019 Sep 23;19:241. 15. Huiyan Hu#, Jingjing Zhao#, Wen Yu, Junwei Zhao, Zhewei Wang, Lin Jin, Yunyun Yu, Lingfei Han, Lu Wang, Huiting Zhu*, Fang Li*, Human papillomavirus DNA, HPV L1 capsid protein and p16INK4a protein as markers to predict cervical lesion progression. Archives of Gynecology and Obstetrics. 2019 Jan, 299(1):141-149. 16. Junwei Zhao#, Lu Wang#, Hui Lin, Wen Yu, Xianghong Xu, Huiyan Hu, Laifang Zhu, Lingfei Han*, Fang Li*, Association of HLA-DRB1/DQB1 polymorphism with high-risk HPV infection and cervical intraepithelial neoplasia women from Shanghai. International Journal of Clinical and Experimental Pathology, 2018.2.15, 11(2):748-756. 17. Yahui Zhang#, Lin Wang#, Xiang Xu#, Fang Li*, Qingsheng Wu*, Combined systems of different antibiotics with nano-CuO against Escherichia coli and the mechanisms involved. Nanomedicine (Lond), 2018 Feb; 13(3):339-351. 18. Xiaojie Huang#, Chao Li#, Fang Li, Junwei Zhao, Xiaoping Wan*, Kai Wang*, Cervicovaginal microbiota composition correlates with the acquisition of high- risk human papillomavirus types. International Journal of Cancer, 2018 Aug 1, 143(3):621-634. 19. Dongsheng Chen#*, Sanjie Jiang, Xiaoyan Ma, Fang Li*, TFBSbank: a platform to dissect the big data of protein-DNA interaction in human and model species. Nucleic Acids Research, 2017.1.4, 45(D1): D151-D157. 20. Xiaohui Zhou#*, Yanfeng Shi, Lijie Wang, Mei Liu, Fang Li*, Distribution Characteristics of Human Papillomavirus Infection: A Study Based on Data from Physical Examination. Asian Pacific Journal of Cancer Prevention, 2017 Jul 27, 18(7):1875-1879. 21. Junwei Zhao#, Fang Fang#, Yi Guo, Tailin Zhu, Yunyun Yu, Fanfei Kong, Lingfei Han, Dongsheng Chen*, Fang Li*, HPV16 integration probably contributes to cervical oncogenesis through interrupting tumor suppressor genes and inducing chromosome instability. Journal of Experimental & Clinical Cancer Research, 2016.11.25, 35(1): 180-180.   22. Yunyun Yu#, Lingfei Han#, Wen Yu, Yankang Duan, Zhewei Wang, Huiyan Hu, Junwei Zhao, Suman Singh, Fanfei Kong, Lin Jin, Jing Sun*, Fang Li*, High risk factors associated with HPV persistence after loop electrosurgical excision procedure in patients with intraepithelial neoplasia. International Journal of Clinical and Experimental Pathology, 2017,10(2):1817-1824. 23. Yi Guo#, Jiachang Hu, Liping Zhu, Jing Sun, Longxu Xie, Fanfei Kong, Lingfei Han, Fang Li*, Physical Status and Variant Analysis of Human Papillomavirus 16 in Women from Shanghai. Gynecologic and Obstetric Investigation, 2016.01.01, 81(1):61-70. 24. Suman Singh#, Qian Zhou#, Yunyun Yu, Xianghong Xu, Xiaojie Huang, Junwei Zhao, Lingfei Han, Kai Wang, Jing Sun*, Fang Li*, Distribution of HPV genotypes in Shanghai women. International Journal of Clinical and Experimental Pathology, 2015.01.01, 8(9): 11901-11908. 25. Lingfei Han#*, Wei Wang#, Jiahong Lu#, Fanfei Kong, Ge Ma, Yiping Zhu, Dong Zhao, Jianlong Zhu, Wen Shuai, Qian Zhou, Ping Chen, Lei Ye, Jie Tao, Sarfraz Ahmad, Fang Li*, Jing Sun*, AAV-sBTLA facilitates HSP70 vaccine-triggered prophylactic antitumor immunity against a murine melanoma pulmonary metastasis model in vivo. Cancer Letters, 2014.11.28, 354(2):398-406. 26. Fang Li#*, Yi Guo, Lingfei Han*, Yankang Duan, Fang Fang, Sumei Niu, Qiujie Ba, Huaishi Zhu, Fanfei Kong, Chao Lin, Xuejun Wen, In vitro and in vivo growth inhibition of drug-resistant ovarian carcinoma cells using a combination of cisplatin and a TRAIL-encoding retrovirus. Oncology Letters, 2012.12.01, 4(6): 1254-1258. 27. Fang Li#*, Qiujie Ba#, Sumei Niu, Yi Guo, Yankang Duan, Peng Zhao, Chao Lin*, Jing Sun*, In-situ forming biodegradable glycol chitosan-based hydrogels: Synthesis, characterization, and chondrocyte culture. Materials Science and Engineering: C, 2012.10.1, 32(7): 2017-2025. 28. Fang Li#*, Jing Sun, Huaishi Zhu, Xuejun Wen, Chao Lin, Donglu Shi, Preparation and characterization novel polymer-coated magnetic nanoparticles as carriers for doxorubicin. Colloids and Surfaces B: Biointerfaces, 2011.11.1, 88(1): 58-62. 29. Xu Song#*, Fang Li#, Jingwei Ma, Nengqin Jia*, Jianming Xu, Hebai Shen*, Synthesis of fluorescent silica nanoparticles and their applications as fluorescence probes. Journal of Fluorescence, 2011.5.01, 21(3):1205-1212. 30. Fang Li#*, Sumei Niu, Jing Sun, Huaishi Zhu, Qiujie Ba, Yi Guo, Donglu Shi, Efficient In Vitro TRAIL-Gene Delivery in Drug-Resistant A2780/DDP Ovarian Cancer Cell Line via Magnetofection. Journal of Nanomaterials, 2011.01.01. 31. Fang Li#*, Pingping Su#, Chao Lin, Hong Li, Jiajing Cheng, Donglu Shi, Ribosome display and selection of human anti-placental growth factor scFv derived from ovarian cancer patients. Protein and Peptide Letters, 2010.5.01, 17(5):585-590. 32. Lin, Chao#*, Peng Zhao#, Fang Li*, Fangfang Guo, Zhuoquan Li, Xuejun Wen, Thermosensitive in situ-forming dextran-pluronic hydrogels through Michael addition. Materials Science and Engineering: C, 2010.01.01, 30(8):1236-1244. 33. Fang Li#*, Jianing Li, Xuejun Wen*, Shenghu Zhou, Xiaowen Tong, Pingping Su, Hong Li, Donglu Shi*, Anti-tumor activity of paclitaxel-loaded chitosan nanoparticles: An in vitro study. Materials Science and Engineering: C, 2009.01.01, 29(8):2392-2397. 34. Fang Li#, Li Meng#, Hui Xing, Jianfeng Zhou, Shixuan Wang, Lei Huang, Gang Xu, Huaishi Zhu, Yunping Lu, Ding Ma*, Essential role of c-Jun-NH2-terminal kinase on synergy induction of apoptosis by TRAIL plus ADM in ADM resistant MCF-7/ADM cells. Apoptosis, 2006.01.01, 11:1239-1246. 35. Fang Li#, Li Meng#, Jianfeng Zhou, Hui Xing, Shixuan Wang, Gang Xu, Huaishi Zhu,Beibei Wang, Gang Chen, Yunping Lu, Ding Ma*, Reversing chemoresistance in cisplatin-resistant human ovarian cancer cells: A role of c-Jun NH(2)-terminal kinase 1. Biochemical and Biophysical Research Communications, 2005.10.01, 335(4):1070-1077. 36. Lei Huang#, Qilin Ao, Qinghua Zhang, Xiaokui Yang, Hui Xing, Fang Li, Gang Chen, Jianfeng Zhou, Shixuan Wang, Gang Xu, Li Meng, YunPing Lu, Ding Ma*, Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1 alpha. Journal of Cancer Research and Clinical Oncology, 2010.3.01, 136(3):447-456. 授权发明专利： 陈惟,李芳,李锋华,李建中. 一种磁共振宫颈线圈，2020.04.21，CN111035388A 李芳,皇甫江涛，一种内置式显微阴道镜，2018.06.01，ZL201710171035.5

毕业于中南大学，从事妇科及妇科肿瘤专业工作30余年，擅长领域：妇科微创手术（腹腔镜、宫腔镜），恶性肿瘤根治性手术，对妇科良、恶性疾病及疑难复杂疾病的诊治有丰富的临床和研究经验。任同济大学东方医院妇产科教研室主任，妇瘤科主任，妇产科国家GCP基地主任。培养博士及硕士研究生40余名，发表学术论文40余篇，宫颈癌早期预警研究获科技进步二等奖，承担国家自然科学基金等多项科研课题。团队成员由数位中青年医学博士，医学硕士组成，富有朝气和探索精神，有丰富的教学经验和科研能力。依托东方医院强大的多学科队伍，实现规范、精准、个体精细化全程化管理的妇科肿瘤多学科诊疗模式；                                                                                         目前的科研方向：主要从事妇科肿瘤基础与临床研究，包括宫颈癌早期预警，以及晚期宫颈癌化疗敏感性,卵巢癌靶向及免疫微环境治疗。近5年主持课题3项，省部级1项，厅局级1项，横向课题1项，发表学术论文14篇，第一作者或通讯作者SCI论文8篇； 参与《中国妇科肿瘤诊治指南 》编写与制订 参编《妇产科临床思维培训教程》                                                                                                    近5年主要论文及课题： 1.DNA methylation of miR-138 regulates cell proliferation and EMT in cervical cancer by targeting EZH2(J).BMC Cancer,2022;22:488. 2.Upregulated Expression of CYBRD1 Predicts Poor Prognosis of Patients with Ovarian Cancer（J).Journal of Oncology, 2021.9:1-14. 3.Prognostic Factors and Local Treatment Modalities of Small-Cell Carcinoma of the Cervix: An Analysis According to the International Federation of Gynecology and Obstetrics Stage (J) .Cancer Management and Research ,2020;12:3445-3456 4.circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTORSignaling (J) .Cancer Management and Research ,，2020;12:3611-3621 5.MicroRNA‑138 inhibits tumor growth and enhances chemosensitivity in human cervical cancer by targeting H2AX(J).Experimental and Therapeutic Medcine,2020;(19),1:630-638 6.Nucleoporin 107 Promotes the Survival of Tumor Cells in Cervical Cancers(J）.Gynecologic and Obsteric Investigation，2020;85(1):41-52 7.绝经后子宫内膜增厚与子宫内膜病变的相关性研究 (J).实用妇产科杂志 2021，1（37）：62-66. 8.间断性下腹痛1+月,腹胀伴呼吸困难3天(J).实用妇产科杂志,2019(35),8:578-580 9.老年妇科肿瘤患者决策途径及综合评估指南要点 (J).实用妇产杂志,2019(35),8:581-583 10.老年子宫内膜癌的诊疗策略(J).实用妇产科杂志,2019(35),8:567-570 11.苦参碱通过P38通路调节H2AX磷酸化抑制宫颈癌细胞的增殖及迁移(J).同济大学学报(医学版),2018(39).004:22-28 12.Analysis of cervical human papillomavirusinfection in 2300 women in Urumqi （J）. China Medicine ,(2018) 97（45）：1-4. 13.高危型人乳头瘤病毒对宫颈病变治疗后监测临床意义研究（J）.中华肿瘤防治杂志,2017,24(4):268-272. 14.MicroRNA-21 promotes endometrial carcinoma proliferation and  invasion by targeting PTEN，Int J Clin（J）. Exp Pathol ,2017,10(12):11489-11495. 15.新疆维吾尔族子宫颈鳞癌microRNA与化疗敏感性的关系研究（项目编号81360380），国家自然科学基金，已结题。 16.DNA甲基化调控miR138-EZH2-上皮钙黏蛋白-EMT通路抑制子宫颈癌细胞转移的功能和机制研究（项目编号201840166），上海市卫计委，20万。 17.尼拉帕利联合二甲双胍对治疗PTEN突变的I型子宫内膜癌的机制基础研究（项目编号：SEHHH-2019(KJ)-0107-KJB-085），横向课题，10万。 18.miRNA金纳米星复合物靶向抑制宫颈癌生长转移的功能和机制研究（项目编号20202ACB206006），江西省自然科学基金重点项目，20万。

承担同济大学、南京医科大学、山西医科大学本科教学科每年4学时，曾带教上海交通大学医学院硕士研究生3名已毕业，锦州医科大学硕士研究生3名，1名已毕业