主持的课题:
1.国家自然科学基金面上项目(82171366):颅脑创伤后星形胶质细胞的外泌体GJA1-20k促进神经元线粒体自噬降解NLRP3炎症小体的保护机制研究,55万,在研,主持
2.江西省杰出青年项目(20202ACBL216005):基于“功能性Cx43对线粒体功能的保护”探讨TBI后星形胶质细胞对神经元的保护机制的研究,20万,在研,主持
3.江西省教育厅科学技术研究重点项目(GJJ190022):GJA1-20k抑制神经元损伤在TBI治疗中分子机制的研究,5万,在研,主持
4.上海市自然科学基金(19ZR1447400):星形胶质细胞的线粒体经TNTs-GJA1纳米通道传输及抗神经元损伤在治疗TBI作用机制中的研究,20万,在研,主持
5. 上海健康医学院种子基金(SFP-18-21-13-007):Cx40/Cx43异型缝隙连接形成与核因子途径的激活参与脑缺血再灌注损伤机制的研究, 5万,已结题,主持
6.浦东新区科委自然科学基金(PKJ2016-Y31):经磷酸化ERK1/2途径形成的Cx40/Cx43缝隙连接重构在大鼠脑缺血模型超急性期的研究,15万,已结题,主持
7.上海市浦东新区优秀青年医学人才培养计划(PWRq-2015-16),19.7万,优秀结题,主持
8. 浦东新区科委自然科学基金(PKJ2012-Y13):Cx40参与创伤性脑水肿发病机制的分子机制研究,12万,已结题,主持
发表的文章
以独立第一及共一作者所发表的文章
1.He B#, Chen W#, Zheng P, et al. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding mir-195 in traumatic brain injury. Aging-US. 2021; 13: Advance Publication.(中科院分区:2区)
2.Chen W, Hong T, Feng JG, et al. Astrocytes-derived exosomes induce neuronal recovery after traumatic brain injury via delivering GJA1-20k. J Tissue Eng Regen M. 2020; 14(3):412-423.(中科院分区:2区)
3.Chen W#, He B#, Zheng P, et al. Astrocytic insulin-like growth factor-1 protect neurons against excitotoxicity. Front Cell Neurosci. 2019.:298. (中科院分区:2区)
4.Chen W, Zhao L, Liu N, et al. Elevated expression of mir-302 cluster improves TBI by inhibiting phosphorylation of Cx43 via ERK signaling. J Chem Neuroanat. 2019; 99:1-8.
5.He B#, Chen W#, Zheng P, et al. Micro-326 decreases tau phosphorylation and neuron apoptosis through inhibition of JNK signaling pathway by targeting VAV1 in Alzheimer,s disease. J Cell Physiol. 2020; 235(1): 480-493. (中科院分区:2区)
6.Chen W#, He B#, Zheng P. Astrocytic IGF-1 prevents excitotoxic downregulation of ADAR1 in calcium dynamics. J Cell Biochem. 2019; 120(6):9097-9103.
7.Chen W, Zheng P, Feng JG, et al. Upregulation of connexin43 is critical for irradiation induced neuroinflammation. CNS& Neurol Disorder-DR. 2018; 17(7):539-546.
8.Chen W, Guo YJ, Tong WS, et al. Phosphorylation of connexin 43 induced by traumatic brain injury promotes exosome release. J Neurophysiol. 2018; 119(1):305-311.
9.Chen W, Guo YJ, Tong WS, et al. Cx40 correated with oxidative stress in brains of TBI rats. Restor Neurol Neurosci. 2017; 35(2):217-224.
10.Chen W, Feng JG, Tong WS. Phosphorylation of astrocytic Cx43 by ERK1/2 impairs BBB in acute cerebral ischemia. Cell Biosci. 2017; 7.:43. (中科院分区:2区)
11.Chen W, Guo YJ, Tong WS, et al. Involvement of autophagy in Cx40 reduction in late phase of TBI in rats. Brain Res Bull. 2017; 131:100-106.
12.Chen W, Guo YJ, Tong WS, et al. Involvement of Cx40 in the protective effects of ginsenoside Rb1 against TBI. Cell Mol Neurobiol. 2016; 36(7):1057-1065. (中科院分区:2区)
13.Chen W, Guo YJ, Tong WS, et al. Protective effect of ginsenoside Rb1 on integrity of BBB following cerebral ischemia. Exp Brain Res. 2015; 233(10):2823-2831.
14.陈伟, 赵麟, 冯九庚, 等. 星形胶质细胞来源的GJA1-20k在氧化应激损伤后参与神经元保护作用的机制. 南京医科大学学报(自然版). 2020; (8): 1098-1104.(CSCD+北大核心)
15.陈伟,任大斌,郑平, 等. 与缺氧诱导因子-1α调控相关的缝隙连接43蛋白磷酸化参与脑缺血再灌注损伤机制. 临床神经外科杂志. 2019; 2:142-146. (统计源核心,高质量科技期刊神经病学领域T3级)
16.陈伟, 郑平, 赵麟, 等. cAMP对大鼠颅脑损伤后神经功能及脑水肿的影响. 中国临床神经外科杂志. 2019; 4:226-229. (统计源核心)
以通讯/共通讯作者发表的文章
1.Zheng P#, Bai QK, Feng JG#,Zou SF*, Chen W*, et al. Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. Bioeng & Transl Med. 2021. DOI:10.1002/btm2.10249.(Top期刊, IF>10)
2.Ren DB#, Zheng P#, Zou SF#, Feng JG*, Zhong CL*, Chen W*, et al.GJA1-20k enhances mitochondria transfer from astrocytes to neurons via Cx43-TnTs after traumatic brain injury. Cell Mol Neurobiol. 2021. DOI:10.1007/s 10571-021-01070-x(中科院分区:2区)
3.Ren DB#, Zheng P#, Feng JG#, Zou SF*, Hong T*, Chen W*, et al. Overexpression of astrocytes-specific GJA1-20k enhances the viability and recovery of the neurons in a rat model of traumatic brain injury. ACS Chem Neurosci, 2020; 11(11):1643-1650. (中科院分区:2区)
4.Zheng P, He B, Chen W*. Inhibition of micro-RNA103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulation BDNF. Cancer Cell Int. 2019.:109.
5.任大斌, 郑平, 陈伟*, 等.抑制ERK1/2对大鼠脑缺血再灌注损伤的保护作用. 中国临床神经外科杂志. 2019; 5:295-298. (统计源核心)
6.施虹, 冯九庚, 陈伟*, 等. 人参皂甙Rb1通过调控缝隙连接蛋白40治疗脑缺血再灌注损伤的机制. 中风与神经疾病杂志. 2019; 3:200-203. (统计源核心+北大核心)