本部心内科执行主任
副教授
毕业于复旦大学,医学博士,副主任医师,副教授,博士生导师,同济大学附属东方医院本部心内科执行主任,曾于2017年在美国访学。主持国家自然科学基金、上海市自然科学基金及江西省自然科学基金面上项目3项,入选2019年远航人才计划和2020年上海市浦东新区学科带头人计划;共发表SCI论文30篇,其中通讯或一作10余篇,受邀参编《Nano Based Drug Delivery》、《心脏病学实践2020》等多部中、英文专著,申请发明专利1项。
中国生物医学工程学会基础研究委员会委员
国家心血管病专家委员会心血管代谢医学专业委员会委员
中国医疗保健国际交流促进会心脏重症分会委员
上海市医学会心血管分会心衰学组委员
《临床心血管病学杂志》和《内科诊疗与进展杂志》编委
2020年度“优秀党员,2020年度徐汇区最美家庭;2021年度优秀住培导师。
一作、共一和通讯作者文章:1. Youming Zhang, Zichun Cai, Yunli Shen, Qizheng Lu, Wei Gao, Xin Zhong, Kang Yao, Jie Yuan, Haibo Liu. Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction. J Nanobiotechnology. 2021 Sep 8;19(1):271. (co-first author)
2. Xueting Gao, Shuai Yu , Yi Guan, Yunli Shen, Liang Xu. Nucleoporin 50 mediates Kcna4 transcription to regulate cardiac electrical activity. J Cell Sci. 2021 Sep 15;134(18):jcs256818.doi: 10.1242/jcs.256818. Epub 2021 Sep 17. (co-correspondence author)
3. Hao Zheng, Jieyun You, Xiaobo Yao , Qizheng Lu , Wei Guo , Yunli Shen. Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes. J Cell Mol Med. 2020 Sep;24(18):11030-11033.doi: 10.1111/jcmm.15722. Epub 2020 Aug 11. ( correspondence author)
4. Shen Y, Gong S, Li J, Wang Y, Zhang X, Zheng H, Zhang Q, You J, Huang Z, Chen Y. Co-loading antioxidant N-acetylcysteine attenuates cytotoxicity of iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes. Int J Nanomedicine. 2019 Aug 1(14):6103-6115.
5. Xie X, Shen Y, Chen J, Huang Z, Ge J. Mineralocorticoid receptor deficiency improves the therapeutic effects of mesenchymal stem cells for myocardial infarction via enhanced cell survival. J Cell Mol Med. 2019 Feb.23(2):1246-1256. (co-first author)
6. Shen Y, Huang Z, Liu X, Qian J, Xu J, Yang X,et al. Iron-induced myocardial injury: an alarming side effect of superparamagnetic iron oxide nanoparticles [J]. J Cell Mol Med, 2015, 19, 2032-2035.
7. Shen Y, Liu X, Huang Z, Pei N, Xu J, Li Z, et al. Comparison of Magnetic Intensities for Mesenchymal Stem Cell Targeting Therapy on Ischemic Myocardial Repair: High Magnetic Intensity Improves Cell Retention but Has no Additional Functional Benefit [J]. Cell Transplant. 2015;24(10):1981-1997.
8. Huang Z, Shen Y, Sun A, Huang G, Zhu H, Huang B, et al. Magnetic targeting enhances retrograde cell retention in a rat model of myocardial infarction[J]. Stem Cell Res Ther, 2013,4(6):149. [co-first author]
9. Huang Z, Shen Y, Pei N, Sun A, Xu J, Song Y, et al. [J]. The effect of nonuniform magnetic targeting of intracoronary- delivering mesenchymal stem cells on coronary embolization.Biomaterials, 2013,34(38):9905-9916. [co-first author]
10. Huang Z, Pei N, Shen Y, Gong Y, Xie X, Sun X, et al. A novel method to delivery stem cells to the injured heart: spatially focused magnetic targeting strategy[J]. J Cell Mol Med, 2012,16(6):1203-1205. [co-first author]